A Forward Vision for Chemodynamic Therapy: Issues and Opportunities

Abstract

Since the insight to fuse Fenton chemistry and nanomedicine into cancer therapy, great signs of progress have been made in the field of chemodynamic therapy (CDT). However, the exact mechanism of CDT is obscured by the unique tumor chemical environment and inevitable nanoparticle-cell interactions, thus impeding further development. In this Scientific Perspective, the significance of CDT is clarified, the complex mechanism is deconstructed into primitive chemical and biological interactions, and the mechanism research directions based on the chemical kinetics and biological signaling pathways are discussed in detail. Moreover, beneficial outlooks are presented to enlighten the evolution of next-generation CDT. Hopefully, this Scientific Perspective can inspire new ideas and advances for CDT and provide a reference for breaking down the interdisciplinary barriers in the field of nanomedicine.

Recent Progress of the Preparation and Application of Electrospun Porous Nanofibers

“…Electrospun porous nanofibers have become a research hotspot, so with the progress and development of electrospinning technology and the unremitting efforts of scientists and researchers, more excellent performances of electrospun porous nanofibers can be developed. The expansion of their applications can be further strengthened along with the fast developments in modern science and technology, such as encapsulating new functional ingredients [ 182 , 183 , 184 ] and additives [ 185 , 186 ], exploring new types of filament-forming polymeric matrices [ 187 , 188 ], being introduced to popular life-improving applications [ 189 , 190 , 191 , 192 , 193 , 194 ], taking advantage of new strategies of synthesizing materials [ 195 , 196 ], and drawing support from traditional techniques for production on a large scale [ 197 , 198 ].…”

Rational designed Fe-ZIFs@CoP nanoplatforms for photothermal-enhanced ROS-mediated tumor therapy

“…Tumors are harmful to human health featuring with increased mortality and causing millions of deaths worldwide ( Zhang et al, 2023a ; Zhao et al, 2023a ; Zhang et al, 2023b ; Gil et al, 2023 ; Yong et al, 2023 ). Compared with early-stage tumors, malignant tumors are not easy to clear, but easy to relapse and metastasize, destroying the structure and function of normal tissues and organs, causing complications such as necrosis, bleeding, and co-infection, and eventually leading to organ failure and death ( Chang et al, 2022 ; Shan et al, 2022 ; Diao and Liu, 2023 ; Li et al, 2023 ; Wang et al, 2023 ).Due to the advances in nanotechnology, rationally designed nanomaterials provide a promising approach for tumor therapy ( Wang et al, 2021a ; Xujiang et al, 2021 ; Yu et al, 2021 ; Zhang et al, 2021 ; Jiang et al, 2023 ).…”

Comprehensively Optimizing Fenton Reaction Factors for Antitumor Chemodynamic Therapy by Charge-Reversal Theranostics

“…Chemodynamic therapy (CDT) is promising for highly selective tumor treatment, , which employs Fenton or Fenton-like agents to catalyze overexpressed hydrogen peroxide (H 2 O 2 ) in a tumor microenvironment (TME) into hydroxyl radicals (·OH) for cell apoptosis and ferroptosis. , However, the limited intratumoral Fenton reaction efficiency has restricted the therapeutic efficacy of CDT; , therefore, CDT is usually combined with other therapies − or assisted by external energy fields − to enhance its therapeutic efficacy. However, these strategies lack solutions to overcome the intrinsic drawbacks of CDT, namely, the inadequate availability of Fenton agents, insufficient acidity and H 2 O 2 concentration in the TME.…”