A formula for the minimal coordination number of a parallel bundle

Starostin, E. L.

doi:10.1063/1.2991413

Cited by 4 publications

(2 citation statements)

References 28 publications

(45 reference statements)

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“…For simplicity, the rods at every folding number n were treated as cylinders with length of l n and a radius of r n (Scheme ). The series of r n (Table ) were obtained from peripheral length of the bundled folded DNA (as the shortest distance formed by a tight string around the bundle) (Figure S1) divided by 2π, with DNA interhelical spacing being 3.04 nm according to small-angle X-ray scattering (SAXS) measurement for PLys/DNA complexes . Thereafter, core surface area of the folded pDNA at folding number n ( A n ) (Table ) was given by the surface of the cylinder side plus the area of both of its ends, A n = [ l n × 2 π r n false] + 2 false[ π r n 2 ] …”

Section: Resultsmentioning

confidence: 99%

Tethered PEG Crowdedness Determining Shape and Blood Circulation Profile of Polyplex Micelle Gene Carriers

et al. 2013

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Surface modification by poly(ethylene glycol) (PEG) onto gene carrier prepared through the electrostatic assembly of pDNA and polycation (polyplex) is a widely acknowledged strategy to advance their systemic application. In this regard, PEG crowdedness on the polyplex surface should give important contribution in determining blood circulation property; however its accurate quantification has never been demonstrated. We report here the first successful determination of PEG crowdedness for PEGylated polyplexes (polyplex micelle) formed from PEG–poly(l-lysine) block copolymers (PEG–PLys) and plasmid DNA (pDNA). Tethered PEG chains were found to adopt mushroom and even squeezed conformation by modulating PEG crowdedness through PLys segment length. Energetic analysis was conducted on the polyplex micelle to elucidate effect of PEG crowdedness on shape and clarify its essential role in regulating packaging structure of pDNA within the polyplex micelle. Furthermore, the PEG crowdedness significantly correlated to blood retention profile, approving its critical role on both shape and systemic circulation property.

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Section: Resultsmentioning

confidence: 99%

Tethered PEG Crowdedness Determining Shape and Blood Circulation Profile of Polyplex Micelle Gene Carriers

et al. 2013

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“…[117][118][119][120][121] We also want to mention that, although locally the lattice of wrapped DNA preserves the hexagonal symmetry to maximize the attraction energy gain from intermolecular contacts, the path taken by a continuous long DNA strand upon wrapping in toroids is still under debate. 122,123 A similar question emerges for DNA packing inside the viral capsids, see section 12.…”

Section: Dna Toroidal Condensationmentioning

confidence: 99%

Electrostatic interactions in biological DNA-related systems

Cherstvy

2011

Phys. Chem. Chem. Phys.

160

148

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In this perspective article, we focus on recent developments in the theory of charge effects in biological DNA-related systems. The electrostatic effects on different levels of DNA organization are considered, including the DNA-DNA interactions, DNA complexation with cationic lipid membranes, DNA condensates and DNA-dense cholesteric phases, protein-DNA recognition, DNA wrapping in nucleosomes, and inter-nucleosomal interactions. For these systems, we develop a theoretical framework to describe the physical-chemical mechanisms of structure formation and anticipate some biological consequences. General biophysical principles of DNA compaction in chromatin fibers and DNA spooling inside viral capsids are discussed in the end, with emphasis on electrostatic aspects.

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