A foreign body reaction to Surgicel® mimicking an abscess following cardiac surgery

Ibrahim, Mohamed F.; Aps, C.; Young, Christopher

doi:10.1016/s1010-7940(02)00328-7

Cited by 73 publications

(61 citation statements)

References 8 publications

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“…1 If left in the body in significant amounts, they can be the focus of severe adverse events including adhesion formation. 1,[12][13][14][15][16] Their appearance as granulomata leads to the suggestion that degradation time might even be longer than weeks. 17 Since 1970, mammalian derived products mostly based on bovine, porcine, or other domestic animal albumin, collagen or gelatin have been used.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the biological tolerability of the starch-based medical device 4DryField® PH in vitro and in vivo a rat model

et al. 2015

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Õ PH was in the range of controls and less than in injured rats without treatment. At day 7 after surgery no formation of adhesions, neither macroscopic nor histological remnants nor signs of foreign body reaction were present in animals without injury. In animals with peritoneal injury and 4DryField Õ PH application, histopathological observation revealed minor residuals of polysaccharide in the depth of wound cavity embedded in a thickened subperitoneal layer; however, with a suggested intact neoperitoneum. The presence of mononuclear cells surrounding polysaccharide particles in varying states of degradation was observable as well. Conclusion: 4DryFieldÕ PH is not cytotoxic and does not enhance viability of tumour cell lines. High dose of 4DryField Õ PH of 1.09 g/kg bodyweight is well tolerated and reduces weight loss in animals with peritoneal injury. The biocompatibility of 4DryField Õ PH can be rated as being excellent.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the biological tolerability of the starch-based medical device 4DryField® PH in vitro and in vivo a rat model

et al. 2015

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“…Ibrahim et al reported a whitish thick cheesy material with the appearance of pus with pieces of non-absorbed oxidized cellulose one year following surgery. 8 The cultures on this material turned out to be sterile with no organisms seen or grown.…”

Section: Discussionmentioning

confidence: 95%

“…7 Some guidelines recommend using it sparingly where its use is indispensible, as many such cases have been attributed to use in excess. 8 The Society of Obstetricians and Gynaecologists of Canada recommends using oxidized cellulose for patients who are at high risk of forming clinically significant adhesions. However, ironically the risk of adhesions may increase if optimal hemostasis is not achieved.…”

Section: Discussionmentioning

confidence: 99%

Oxidized cellulose: an unusual cause of post hysterectomy hemorrhage

Amrita

Jain

Sharma

et al. 2016

Int J Reprod Contracept Obstet Gynecol

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“…In fact, oxidised cellulose granulomata may mimic tumour recurrence [9] or postoperative abscess [7,10] on both CT and sonography when a patient undergoes imaging early in the postoperative period [11]. Oto described the appearance of oxidised, regenerated cellulose on postoperative MR imaging with a short relaxation time on T2-weighted images, resulting in low signal intensity in the early postoperative period.…”

Section: Discussionmentioning

confidence: 99%

Haemostasis in spine surgery. The use of local agents: Surgicel and Surgifoam

2004

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IntroductionAchieving haemostasis during surgical procedures within the spinal canal is of paramount importance. Whereas bleeding of up to one litre may be tolerated within structures such as the abdominal cavity, bleeding of only a few millilitres within the spinal canal may cause devastating neurological damage. In addition, microsurgical approaches to intraspinal structures depend on clear visualisation of the most delicate structures: continuous bleeding may impede identification of eloquent and/or pathological structures. Mechanical methods of haemostasis such as direct pressure and ligature are not applicable in intraspinal surgery because of the depth at which the surgery is performed and the indispensability of structures. For most of this century, the mainstay of controlling intraspinal bleeding has been bipolar cautery, allowing precise coagulation of small vessels, and, compared to monopolar cautery, minimizing the dangerous spread of current to adjacent tissue. Intraspinal, intradural and intramedullary bipolar cautery, however, has severe drawbacks. The complete occlusion of the vessel lumen may compromise the perfusion of the neural tissue supplied by the cauterized vessel. In addition, dissipation of heat from the tips of the bipolar forceps may induce thermal injury to adjacent vascular and neural structures. Though bipolar cautery is most effectively used to occlude identifiable vessels, it has minimal efficacy in controlling the diffuse capillary bleeding that characterises most intraspinal pathologies. For these reasons chemical haemostatic agents are often preferable to bipolar cautery in intraspinal procedures. These products can control bleeding without occluding the vessel lumen and cause no thermal injuries to adjacent structures. When applied topically, these agents can effectively control diffuse capillary oozing. General remarksIn the majority of intraspinal, extradural procedures, bleeding is caused by venous vessels. This low-pressure bleeding will eventually stop when the patient is repositioned in the supine position and the intraspinal counter-pressure exceeds the intravenous pressure. However, due to venous compression, dilated varicose intraspinal veins may be a source of continuous bleeding, thereby impeding visualiAbstract There are various electrical, mechanical and chemical methods used to achieve haemostasis in spine surgery. Chemical haemostatic agents are often preferable to bipolar cautery in intraspinal procedures, because these products control bleeding without occluding the vessel lumen and cause no thermal injuries to adjacent structures. A topical haemostat is the often the technique of choice to control bleeding from bone and to diffuse capillary and epidural venous oozing. This paper focuses on technical aspects of the application of absorbable porcine gelatine and regenerated, oxidised cellulose. These haemostats have been used in neurosurgical intraspinal procedures for more than 30 years; however, new application forms like Surgicel fibrillar and Surgifoam powd...

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A foreign body reaction to Surgicel® mimicking an abscess following cardiac surgery

Cited by 73 publications

References 8 publications

Evaluation of the biological tolerability of the starch-based medical device 4DryField® PH in vitro and in vivo a rat model

Evaluation of the biological tolerability of the starch-based medical device 4DryField® PH in vitro and in vivo a rat model

Oxidized cellulose: an unusual cause of post hysterectomy hemorrhage

Haemostasis in spine surgery. The use of local agents: Surgicel and Surgifoam

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