A Follow-up Study on Alcoholics with and without Co-existing Affective Disorder

O'Sullivan, K; Rynne, C; Miller, John P.; O’Sullivan, Shaunagh; Fitzpatrick, Veronica; Hux, Margaret; Cooney, John; Clare, Anthony W.

doi:10.1192/bjp.152.6.813

Cited by 63 publications

(22 citation statements)

References 12 publications

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“…Depression in community populations is associated with premature drop-out from addiction treatment (Brown, 1997). With few exceptions (Carroll et al, 1995; Gerra et al, 2006), depression is also associated with poorer prognosis in community addiction treatment (Bottlender & Soyka, 2005; Brown et al, 1997; Brown et al, 1998; Kosten et al, 1986; McKay et al, 2002; O'Sullivan et al, 1988; Richardson et al, 2008; Rounsaville et al, 1987; Rounsaville et al, 1986a; Rounsaville et al, 1986b; Thase et al, 2001), despite higher treatment motivation (Joe et al, 1995; McKay et al, 2002; see also Rounsaville, 2004). In correctional populations, MDD and depressive symptoms strongly predict dropout from correctional substance use programs (Brady et al, 2004; Gray & Saum, 2005; Hickert et al, 2009; Hiller et al, 1999) and poorer addiction treatment outcomes (Johnson et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Pilot study of treatment for major depression among women prisoners with substance use disorder

Johnson

Zlotnick

2012

Journal of Psychiatric Research

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This study, the largest randomized controlled trial of treatment for major depressive disorder (MDD) in an incarcerated population to date, wave-randomized 38 incarcerated women (6 waves) in prison substance use treatment with MDD to group interpersonal psychotherapy (IPT) or to an attention-matched control. Intent-to-treat analyses found that IPT participants had significantly lower depressive symptoms at the end of 8 weeks of in-prison treatment than did control participants. Control participants improved later, after prison release. IPT's rapid effect on MDD within prison may reduce serious in-prison consequences of MDD.

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Section: Introductionmentioning

confidence: 99%

Pilot study of treatment for major depression among women prisoners with substance use disorder

Johnson

Zlotnick

2012

Journal of Psychiatric Research

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“…A strong link of depression with substance use and impairment would suggest that depressed substance users may require enhanced treatment interventions. Data also suggest that depression is associated with greater treatment involvement (Burns et al, 2005) and use of more treatment services (O’Sullivan et al, 1988; Schuckit, 1985). …”

Section: Introductionmentioning

confidence: 99%

Meta-analysis of depression and substance use among individuals with alcohol use disorders

Conner

Pinquart

Gamble

2009

Journal of Substance Abuse Treatment

282

193

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The relationships of depression with alcohol and drug use and impairment were examined. Additional analyses were conducted to examine moderators of these associations. Empirical reports on adults with alcohol abuse or dependence published in English in peer-reviewed journals since 1986 that contained data on depression and substance use variable(s) were obtained using a systematic search. The search yielded 74 studies including 58 reports from clinical venues, 10 that were community-based, and 6 with subjects from both settings. As hypothesized, the analyses showed that depression is associated with concurrent alcohol use and impairment and drug use and impairment. Effect sizes were small. Depression was also related to future alcohol use and impairment, an earlier age of onset of an AUD, and higher treatment participation. Age moderated the association between depression and alcohol use and impairment such that the association was stronger in older samples.

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“…Major depression and alcoholism are often comorbid (Schuckit, 1986;O'Sullivan et al, 1988;Herz et al, 1990;Buydens-Branchey et al, 1989;Roy et al, 1991a, b;Cornelius et al, 1995Cornelius et al, , 1996Davidson and Blackburn, 1998;Spak et al, 2000;McGrath et al, 2000;Gilman and Abraham, 2001;Thase et al, 2001). Schuckit (1986), suggests that between one-quarter and two-thirds of subjects with alcoholism have had depressive symptoms severe enough to interfere with functioning.…”

Section: Introductionmentioning

confidence: 99%

“…Schuckit (1986), suggests that between one-quarter and two-thirds of subjects with alcoholism have had depressive symptoms severe enough to interfere with functioning. Depressed subjects with alcoholism have more chronic impairment and suicidal behavior than individuals with either diagnosis alone (O'Sullivan et al, 1988;Cornelius et al, 1995Cornelius et al, , 1996Thase et al, 2001). …”

Section: Introductionmentioning

confidence: 99%

Lower CSF Homovanillic Acid Levels in Depressed Patients with a History of Alcoholism

Sher

Oquendo

et al. 2003

Neuropsychopharmacol

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Major depression and alcoholism are often comorbid, resulting in more impairment and more suicidal behavior compared with either diagnosis alone. This study compared clinical features and cerebrospinal fluid (CSF) monoamine metabolites in depressed subjects with and without a history of alcoholism and healthy volunteers. We hypothesized that depressed subjects with a history of alcoholism would be more aggressive, impulsive, and suicidal than depressed subjects without a history of alcoholism, and would have lower CSF monoamine metabolite levels. We compared 63 subjects with a current major depressive episode (MDE) and a history of alcoholism, 72 subjects with a current MDE but without a history of alcoholism, and 22 healthy volunteers. Participants with a history of alcoholism were in remission for at least 6 months. All subjects were free from prescribed medications known to affect brain serotonin, dopamine, or norepinephrine systems for a minimum of 14 days. Depressive symptoms, lifetime aggression, impulsivity, Axis II disorders, and suicidal behavior were assessed. CSF was sampled and homovanillic acid (HVA), 5-hydroxyindolacetic acid (5-HIAA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) were assayed by high-performance lipid chromatography with electrochemical detection. Depressed subjects with a history of alcoholism did not differ from depressed subjects without a history of alcoholism in current severity of depressive symptoms, or in past suicidal behavior. Depressed subjects with a history of alcoholism had lower CSF HVA levels, and higher lifetime aggression and current suicide ideation scale scores and were more likely to be tobacco smokers compared with depressed subjects without a history of alcoholism. Low HVA was present after adjustment for sex, aggression and depression scores, cigarette smoking, antisocial and borderline personality disorders, psychomotor retardation, and delusions. Controls had CSF HVA levels intermediate between the two depressed groups. We found no group difference in CSF 5-HIAA and MHPG levels. In individuals with current MDE, those with a history of comorbid alcoholism had lower CSF HVA levels compared with those without a history of alcoholism. Low CSF HVA suggests that impaired dopaminergic activity is associated with a history of alcoholism in persons with current MDE.

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A Follow-up Study on Alcoholics with and without Co-existing Affective Disorder

Cited by 63 publications

References 12 publications

Pilot study of treatment for major depression among women prisoners with substance use disorder

Pilot study of treatment for major depression among women prisoners with substance use disorder

Meta-analysis of depression and substance use among individuals with alcohol use disorders

Lower CSF Homovanillic Acid Levels in Depressed Patients with a History of Alcoholism

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