A follow-up study of combined vaccination with plasma-derived and recombinant hepatitis B vaccines in infants

Lee, Ping–Ing; Lee, Chin‐Yun; Huang, Li‐Min; Chen, Jong-Min; Chang, Mei–Hwei

doi:10.1016/0264-410x(95)00108-d

Cited by 27 publications

(15 citation statements)

References 21 publications

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“…There might be an overlapping period that the students received PDHBV and RYHBV combination. Lee et al . revealed that a combined vaccination with PDHBV and RYHBV was both protective and immunogenic, and did not affect the immunogenicity.…”

Section: Discussionmentioning

confidence: 99%

Higher disappearance rate of anti‐HBs in Taiwanese freshers neonatally vaccinated with recombinant yeast hepatitis B vaccine

Hsu

Chih

Lee

et al. 2017

Liver International

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Section: Discussionmentioning

confidence: 99%

Higher disappearance rate of anti‐HBs in Taiwanese freshers neonatally vaccinated with recombinant yeast hepatitis B vaccine

Hsu

Chih

Lee

et al. 2017

Liver International

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“…In order to control the vertical transmission of HBV, neonatal immunisation programmes involving the use of immunoglobulin and hepatitis B vaccine have been adopted in many countries [28, 29]. In Hong Kong, this programme was introduced in 1983, following a prospective randomized study that had proved its efficacy [10, 30].…”

Section: Knowledge On Vertical Transmission and Its Preventionmentioning

confidence: 99%

Deficient Knowledge on Hepatitis B Infection in Pregnant Women and Prevalence of Hepatitis B Surface Antigen Carriage in an Endemic Area: A Review

Chan

Lao

Suen

et al. 2012

Hepatitis Research and Treatment

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Hepatitis B infection is a major global health problem. Vertical transmission is the commonest route of spreading hepatitis B virus (HBV) in many endemic areas. In order to control such transmission in Hong Kong, neonatal immunization programme was implemented for more than two decades. A declining prevalence of HBV infection was expected. However, the prevalence remained unabated at around 10% in recent studies. We suspect that one of the explanations of this persistent high prevalence is deficient knowledge on infection with the HBV and its prevention. Our paper gives an overview of the knowledge on HBV infection among Chinese population in both high and low endemic areas and discusses the potential factors that influenced the knowledge on as well as the implication of the sources of information for HBV infection, which was not addressed in previous studies.

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“…Widespread vaccination further led to a dramatic reduction in the incidence of hepatocellular carcinoma in children between 6 and 15 years, and therefore the hepatitis B vaccine is also the first vaccine shown to be effective for the prevention of cancer [14]. However, high-risk infants who have been protected from hepatitis B by the administration of HBIg and HBV vaccine soon after birth still have a carrier rate of 5-10% [42].…”

Section: Hbsag-based Active and Passive Immunizationmentioning

confidence: 99%

Vaccine- and Hepatitis B Immune Globulin-Induced Escape Mutations of Hepatitis B Virus Surface Antigen

Cooreman

Leroux‐Roels

Paulij³

2001

Journal of Biomedical Science

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Hepatitis B virus surface antigen (HBsAg) vaccination has been shown to be effective in preventing hepatitis B virus (HBV) infection. The protection is based on the induction of anti-HBs antibodies against a major cluster of antigenic epitopes of HBsAg, defined as the ‘a’ determinant region of small HBsAg. Prophylaxis of recurrent HBV infection in patients who have undergone liver transplantation for hepatitis B-related end-stage liver disease is achieved by the administration of hepatitis B immune globulins (HBIg) derived from HBsAg-vaccinated subjects. The anti-HBs-mediated immune pressure on HBV, however, seems to go along with the emergence and/or selection of immune escape HBV mutants that enable viral persistence in spite of adequate antibody titers. These HBsAg escape mutants harbor single or double point mutations that may significantly alter the immunological characteristics of HBsAg. Most escape mutations that influence HBsAg recognition by anti-HBs antibodies are located in the second ‘a’ determinant loop. Notably, HBsAg with an arginine replacement for glycine at amino acid 145 is considered the quintessential immune escape mutant because it has been isolated consistently in clinical samples of HBIg-treated individuals and vaccinated infants of chronically infected mothers. Direct binding studies with monoclonal antibodies demonstrated a more dramatic impact of this mutation on anti-HBs antibody recognition, compared with other point mutations in this antigenic domain. The clinical and epidemiological significance of these emerging HBsAg mutants will be a matter of research for years to come, especially as data available so far document that these mutants are viable and infectious strains. Strategies for vaccination programs and posttransplantation prophylaxis of recurrent hepatitis need to be developed that may prevent immune escape mutant HBV from spreading and to prevent these strains from becoming dominant during the next decennia.

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A follow-up study of combined vaccination with plasma-derived and recombinant hepatitis B vaccines in infants

Cited by 27 publications

References 21 publications

Higher disappearance rate of anti‐HBs in Taiwanese freshers neonatally vaccinated with recombinant yeast hepatitis B vaccine

Higher disappearance rate of anti‐HBs in Taiwanese freshers neonatally vaccinated with recombinant yeast hepatitis B vaccine

Deficient Knowledge on Hepatitis B Infection in Pregnant Women and Prevalence of Hepatitis B Surface Antigen Carriage in an Endemic Area: A Review

Vaccine- and Hepatitis B Immune Globulin-Induced Escape Mutations of Hepatitis B Virus Surface Antigen

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