A Follow-Up Study of Cleft Children Treated with Primary Bone Grafting: I.Orthodontic Aspects

Juvenile Swine Surgical Alveolar Cleft Model to Test Novel Autologous Stem Cell Therapies

“…[4][5][6][7] Delayed repair of the alveolar cleft using cancellous bone from the iliac crest has eliminated growth restriction, but it still requires a secondary surgical site. 7 Tissue-engineered strategies offer a promising alternative to the current treatment strategy, but require proof of equivalence to the current gold standard treatment (or evidence of improved efficacy), and safety, both in vitro, and in large animal models, before translation to humans.…”

“…As these patients matured, it became evident that early treatment led to growth restriction of the surrounding craniofacial skeleton and was predisposed to resorption. 4 As a consequence these patients demonstrated poorer outcomes, requiring additional, more complex, surgeries at skeletal maturity. 5,6 Because of these concerns, an alternative strategy of delaying the graft until mixed dentition (8-10 years of age) came into favor.…”

Traitement orthodontique dans les fentes labio-palatines au Mexique

“…Le traitement dure jusqu'à obtention d'une relation et d'une position adéquates du maxillaire et de la mandibule. Les consultations sont mensuelles et, à la fin de cette étape, on évalue une nouvelle fois les relations dentaires et squelettiques [18][19][20].…”

Early secondary closure of alveolar clefts with mandibular symphyseal bone grafts and β-tri calcium phosphate (β-TCP)

“…Reports advocating the use of mandibular symphyseal bone, 9,20,26 rib bone, 18 calvarial bone 14,37,39 and bone harvested from the tibia have been published. 21,30 Harvesting an autologous bone graft has several disadvantages. Donor site surgery requires prolonged operating time and may cause morbidity.…”

“…Successful grafting allows eruption of teeth into the former cleft area and the achievement of orthodontic movement of teeth adjacent to the cleft site, to obtain non-prosthodontic rehabilitation. 2,8,11 Secondary alveolar bone grafting (SABG) is ideally carried out between 9 and 11 years of age, before eruption of the maxillary canine, 21 to allow the canine to erupt through the grafted site. 1,2,8,17 A slight reduction in anterior vertical maxillary growth has been found after SABG.…”