“…2 In rat acute renal allograft rejection models, elevation of IL-17 proteins in day 2 after transplant has been shown. 22,23 In mouse heart transplant model, using IL-17 inhibitor, reduced production of inflammatory cytokines within the graft and increased graft survival. 24 The role of Th17 and IL-17 in liver transplant is not studied much in humans, but reported a significant increase of IL-17/IL-23 protein level in patients with acute rejection after liver transplant; 25,26 Also, our recent study 4 showed the increase of IL-17 mRNA level in the first week after liver transplant in rejected ones.…”