A Focus on Chronic Rhinosinusitis with Nasal Polyposis: Leaving Aside Endoscopic Surgery, a Step towards Biologic Therapies

Abstract

Traditional surgical treatment of chronic rhinosinusitis with nasal polyps is not always definitive since a high rate of polyps recurrence is reported all over the world. Precision medicine, with the utilization of biological therapies, could be a new opportunity for accurately selected patients with nasal polyp's regrowth that underwent previous surgery. In this review we provide a brief historiography of the surgical treatments of chronic rhinosinusitis with/without nasal polyps and describe the first applications of biological therapies.