A Fob1 independent role for the Smc5/6 complex in the rDNA that modulates lifespan

Abstract

Highlights:• Smc5/6 is important for transcriptional silencing in the rDNA.• Smc5/6 tethers the rDNA array to the periphery.• Transcriptional silencing of ncRNA at NTS1 and NTS2 is differentially regulated.• Smc5/6 has a role in rDNA maintenance independent of HR processing at the RFB.• Fob1-independent disruption of Smc5/6 at NTS2 leads to lifespan reduction .