A fMRI study of word retrieval in aphasia

Perani, Daniela; Cappa, Stefano F.; Tettamanti, Marco; Rosa, Mário Miguel; Scifo, Paola; Miozzo, Antonio; Basso, Anna; Fazio, Ferruccio

doi:10.1016/s0093-934x(02)00561-8

Cited by 156 publications

(115 citation statements)

References 40 publications

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“…The role of the L SMA in conjunction with this shift was associated with sustained, improved naming up to almost 4 yr. post-TMS in P1. These results for the good responder are compatible with other functional imaging studies where activation of remaining LH language regions were associated with better recovery (Heiss, Kessler, Thiel, Ghaemi, & Karbe, 1999;Heiss & Thiel, 2006;Perani et al, 2003;Warburton, Price, Swinburn, & Wise, 1999) and with studies that show new LH activation after speech therapy is associated with language improvement (Cornelissen et al, 2003;Leger et al, 2002;Meinzer et al, 2008;Small, Flores, & Noll, 1998).…”

Section: Discussionsupporting

confidence: 89%

“…The LH may be important for better language recovery after stroke (Cao, Vikingstad, George, Johnson, & Welch, 1999;Gold & Kertesz, 2000;Heiss, Kessler, Thiel, Ghaemi, & Karbe, 1999;Karbe et al, 1998;Naeser et al, 2004;Perani et al, 2003;Rosen et al, 2000;Warburton, Price, Swinburn, & Wise, 1999;Zahn et al, 2002). Heiss & Thiel (2006) have suggested that for long-term recovery, RH recruitment may be less efficient than restoring the LH network.…”

Section: Introductionmentioning

confidence: 99%

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Overt naming fMRI pre- and post-TMS: Two nonfluent aphasia patients, with and without improved naming post-TMS

Martin

Naeser

et al. 2007

Brain and Language

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Two chronic, nonfluent aphasia patients participated in overt naming fMRI scans, pre-and post-a series of repetitive transcranial magnetic stimulation (rTMS) treatments as part of a TMS study to improve naming. Each patient received ten, 1-Hz rTMS treatments to suppress a part of R pars triangularis. P1 was a 'good responder' with improved naming and phrase length; P2 was a 'poor responder' without improved naming.Pre-TMS (10 yr. poststroke), P1 had significant activation in R and L sensorimotor cortex, R IFG, and in both L and R SMA during overt naming fMRI (28% pictures named. At 3 mo. post-TMS (42% named), P1 showed continued activation in R and L sensorimotor cortex, R IFG, and in R and L SMA. At 16 mo. post-TMS (58% named), he also showed significant activation in R and L sensorimotor cortex mouth and R IFG. He now showed a significant increase in activation in the L SMA compared to pre-TMS and at 3 mo. post-TMS (p<.02; p<.05, respectively). At 16 mo. there was also greater activation in L than R SMA (p<.08). At 46 mo. post-TMS (42% named), this new LH pattern of activation continued. He improved on the Boston Naming Test from 11 pictures named pre-TMS, to scores ranging from 14-18 pictures, post-TMS (2 mo. to 43 mo. post-TMS). His longest phrase length (Cookie Theft picture) improved from 3 words pre-TMS, to 5-6 words post-TMS.Pre-TMS (1.5 yr. poststroke), P2 had significant activation in R IFG (3% pictures named). At 3 and 6 mo. post-TMS, there was no longer significant activation in R IFG, but significant activation was present in R sensorimotor cortex. On all three fMRI scans, P2 had significant activation in both the L and R SMA. There was no new, lasting perilesional LH activation across sessions for this patient. Over time, there was little or no change in his activation. His naming remained only at 1-2 pictures during all three fMRI scans. His BNT score and longest phrase length remained at 1 word, post-TMS.Lesion site may play a role in each patient's fMRI activation pattern and response to TMS treatment. P2, the poor responder, had an atypical frontal lesion in the L motor and premotor cortex that extended Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. The fMRI data of our patient who had good response following TMS support the notion that restoration of the LH language network is linked in part, to better recovery of naming and phrase length in nonfluent aphasia. NIH Public Access

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Overt naming fMRI pre- and post-TMS: Two nonfluent aphasia patients, with and without improved naming post-TMS

Martin

Naeser

et al. 2007

Brain and Language

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“…These were the conclusions of a PET study, which found bilateral activation in anterior insulae elicited by sentence stimuli (Wong et al, 2002). Right hemisphere frontal areas offer resources to maintain language function and this points to the high likelihood of a pre-existing language network in the right hemisphere that can be recruited when needed (Perani et al, 2003;Voets et al, 2006;Winhuisen et al, 2005). For example, a number of reports indicate that language dominance shifts to homologous righthemisphere regions following a disabling left hemisphere brain injury (Lazar et al, 2000;Staudt et al, 2002;Tivarus et al, 2012).…”

Section: Receptive and Expressive Languagementioning

confidence: 79%

The role of the insula in speech and language processing

2014

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Lesion and neuroimaging studies indicate that the insula mediates motor aspects of speech production, specifically, articulatory control. Although it has direct connections to Broca's area, the canonical speech production region, the insula is also broadly connected with other speech and language centres, and may play a role in coordinating higher-order cognitive aspects of speech and language production. The extent of the insula's involvement in speech and language processing was assessed using the Activation Likelihood Estimate (ALE) method. Meta-analyses of 42 fMRI studies with healthy adults were performed, comparing insula activation during performance of language (expressive and receptive) and speech (production and perception) tasks. Both tasks activated bilateral anterior insulae. However, speech perception tasks preferentially activated the left dorsal mid-insula, whereas expressive language tasks activated left ventral mid-insula. Results suggest distinct regions of the mid-insula play different roles in speech and language processing.

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“…34 Recent fMRI studies have demonstrated robust activation by the WFT in the left Brodmann's area (BA) 44/45, as well as adjacent BA46 and BA47, together with the premotor cortex (BA6) and insula. 35 Previous studies using NIRS [23][24][25][26] demonstrated bilateral frontal activation during the WFT in healthy controls, suggesting that not only the left, but also the right frontal lobe may play crucial roles in voluntary speech intention and/or attentional resources required for performing the WFT. Interconnected areas such as these are believed to participate in a functional language network subserving word output.…”

Section: Discussionmentioning

confidence: 96%

Differentiating early and late‐onset depression with multichannel near‐infrared spectroscopy

et al. 2008

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Background: Individuals with late-life depression can be divided into two categories, those with early and late-onset depression (EOD and LOD, respectively). It has been reported that LOD has more accentuated subcortical vascular lesions and frontal lobe dysfunction (hypofrontality). The aim of the present study was to examine whether LOD exhibits more prominent hypofrontality than EOD during performance of the word fluency task (WFT) under multichannel near-infrared spectroscopy (NIRS), a newly developed non-invasive functional neuroimaging technique. Methods: Eleven patients with EOD, 12 patients with LOD, and 13 healthy controls participated in the study. Clinical symptoms of depression were equivalent in the EOD and LOD groups. Brain magnetic resonance imaging demonstrated more robust subcortical vascular changes in LOD than EOD. The NIRS images were obtained using an ETG-4000, 52-channel NIRS system (Hitachi Medical, Tokyo, Japan). Mean changes in oxy-hemoglobin (oxy-Hb) were evaluated while the participants performed the phonemic WFT. Results: Healthy controls exhibited clear increases in oxy-Hb bilaterally throughout the medial to the lateral frontal cortices and the superior temporal areas during the WFT. In contrast, increases in oxy-Hb were mildly attenuated in EOD and severely attenuated in LOD in most channels. Subsequent analyses revealed that increases in oxy-Hb in LOD during the WFT was significantly poorer than in EOD in the left lateral portion of the cortex, including the dorsolateral prefrontal and the superior temporal areas. In addition, significant negative correlations were obtained between the age of onset and oxy-Hb, as well as between subcortical vascular changes and oxy-Hb in the lateral channels. These findings suggest that the higher the age of onset of depression, and the more prominent the vascular lesions, the greater the attenuation in lateral frontal and temporal activation, as indicated by NIRS. Conclusions: Multichannel NIRS is useful for demonstrating attenuated functional activation in the left lateral prefrontal and temporal areas in LOD and, thus, for differentiating between LOD and EOD. The NIRS findings observed may have useful clinical implications for treatment-resistant LOD.

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A fMRI study of word retrieval in aphasia

Cited by 156 publications

References 40 publications

Overt naming fMRI pre- and post-TMS: Two nonfluent aphasia patients, with and without improved naming post-TMS

Overt naming fMRI pre- and post-TMS: Two nonfluent aphasia patients, with and without improved naming post-TMS

The role of the insula in speech and language processing

Differentiating early and late‐onset depression with multichannel near‐infrared spectroscopy

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