A fluttering coronary event

Zakaria, A.F.; Al-Share, Bayan; Kaspar, Georgy; Small, Delano

doi:10.4103/jfmpc.jfmpc_117_17

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…Acute coronary syndrome (ACS) describes a broad spectrum of clinical symptoms compatible with acute myocardial ischemia, from unstable angina to non‐ST‐segment elevation myocardial infarction (NSTEMI) and ST‐segment elevation myocardial infarction (STEMI) 1,2 . These symptoms are consequences of partial or complete thrombus formation related to the rupture of coronary atherosclerotic plaques.…”

Section: Introductionmentioning

confidence: 99%

Assessment of serum phenylalanine and tyrosine isomers in patients with ST‐segment elevation vs non‐ST‐segment elevation myocardial infarction

Al-Sadoon

Wittmann

Kun

et al. 2020

Clinical Laboratory Analysis

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Background Under conditions of oxidative stress, hydroxyl radicals can oxidize phenylalanine (Phe) into various tyrosine (Tyr) isomers (meta‐, ortho‐, and para‐tyrosine; m‐, o‐, and p‐Tyr), depending on the location of the hydroxyl group on the oxidized benzyl ring. This study aimed to compare patients with ST‐segment elevation myocardial infarction (STEMI) and non‐STEMI (NSTEMI) and the serum levels of Phe and Tyr isomers at the aortic root and distal to the culprit lesion in both groups. Methods Forty‐four patients participated in the study: 23 with STEMI and 21 with NSTEMI. Arterial blood samples were taken from the aortic root through a guiding catheter and from the culprit vessel segment distal from the primary lesion with an aspiration catheter, during the percutaneous coronary intervention. Serum levels of Phe, p‐Tyr, m‐Tyr, and o‐Tyr were determined using reverse‐phase high‐performance liquid chromatography. Results Serum levels of Phe were significantly higher distal to the culprit lesion compared to the aortic root in patients with STEMI. Serum p‐Tyr/Phe and m‐Tyr/Phe concentration ratios were both lower distal to the culprit lesion than at the aortic root in patients with STEMI. There were no statistically significant differences with respect to changes in serum Phe and Tyr isomers distal to the culprit lesion compared to the aortic root in patients with NSTEMI. Conclusion Our data suggest that changes in serum levels of different Tyr isomers can mediate the effects of oxidative stress during myocardial infarction.

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Section: Introductionmentioning

confidence: 99%

Assessment of serum phenylalanine and tyrosine isomers in patients with ST‐segment elevation vs non‐ST‐segment elevation myocardial infarction

Al-Sadoon

Wittmann

Kun

et al. 2020

Clinical Laboratory Analysis

View full text Add to dashboard Cite

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Acute Coronary Syndrome (ACS) due to Coronary Artery Embolism in a Patient with Atrial Fibrillation

Daoud

Abugroun

Erramilli

et al. 2019

Case Reports in Cardiology

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Acute coronary syndrome (ACS) secondary to a coronary embolism is an unusual occurrence, yet an important consideration given the difficult diagnosis. We report a case of a 69-year-old male with a medical history of paroxysmal atrial fibrillation who presented with chest pain and shortness of breath. A coronary angiogram was significant for three focal transluminal and translucent areas in the ostial, mid, and distal circumflex artery consistent with embolic disease. The patient was subsequently managed medically with anticoagulation. Despite being a relatively rare entity, thromboembolism into the coronary arteries can provoke an acute myocardial infarction, with atrial fibrillation being the most common risk factor. Treatment modalities for ACS secondary to thromboembolism include stent placement, intracoronary thrombolysis, and thrombus aspiration.

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A fluttering coronary event

Cited by 2 publications

References 10 publications

Assessment of serum phenylalanine and tyrosine isomers in patients with ST‐segment elevation vs non‐ST‐segment elevation myocardial infarction

Assessment of serum phenylalanine and tyrosine isomers in patients with ST‐segment elevation vs non‐ST‐segment elevation myocardial infarction

Acute Coronary Syndrome (ACS) due to Coronary Artery Embolism in a Patient with Atrial Fibrillation

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