A Fluorogenic Probe with Aggregation‐Induced Emission Characteristics for Carboxylesterase Assay through Formation of Supramolecular Microfibers

Wang, Xiaojing; Liu, Huan; Li, Jingwen; Ding, Kaiguo; Lv, Zhonglin; Yang, Yonggang; Chen, Hong; Li, Xinming

doi:10.1002/asia.201301326

Cited by 38 publications

(22 citation statements)

References 52 publications

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“…The space limitation forces us to be highly selective in choosing examples for presentation and discussion. As a compensation to this pitiful loss, we herein provide a list of selected papers published recently by different research groups in the area in the Reference Section . Although much work has been done in the area, many intriguing possibilities remain to be explored.…”

Section: Summary and Perspectivementioning

confidence: 99%

Aggregation‐Induced Emission: The Whole Is More Brilliant than the Parts

et al. 2014

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"United we stand, divided we fall."--Aesop. Aggregation-induced emission (AIE) refers to a photophysical phenomenon shown by a group of luminogenic materials that are non-emissive when they are dissolved in good solvents as molecules but become highly luminescent when they are clustered in poor solvents or solid state as aggregates. In this Review we summarize the recent progresses made in the area of AIE research. We conduct mechanistic analyses of the AIE processes, unify the restriction of intramolecular motions (RIM) as the main cause for the AIE effects, and derive RIM-based molecular engineering strategies for the design of new AIE luminogens (AIEgens). Typical examples of the newly developed AIEgens and their high-tech applications as optoelectronic materials, chemical sensors and biomedical probes are presented and discussed.

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Section: Summary and Perspectivementioning

confidence: 99%

Aggregation‐Induced Emission: The Whole Is More Brilliant than the Parts

et al. 2014

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“…In this regard, AIE probes with phosphate groups were developed for sensing of alkaline phosphatase (ALP). 36 A single AIE probe could also be designed to recognize multiple targets via different interactions to produce distinct signals. Upon incubation with ALP, the phosphate group was cleaved by hydrolysis reaction, yielding a hydrophobic product which emitted strongly in the same media.…”

Section: Aie-small Molecule Conjugatesmentioning

confidence: 99%

Specific light-up bioprobes based on AIEgen conjugates

2015

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Driven by the high demand for sensitive and specific tools for optical sensing and imaging, bioprobes with various working mechanisms and advanced functionalities are flourishing at an incredible speed. Conventional fluorescent probes suffer from the notorious effect of aggregation-caused quenching that imposes limitation on their labelling efficiency or concentration to achieve desired sensitivity. The recently emerged fluorogens with an aggregation-induced emission (AIE) feature offer a timely remedy to tackle the challenge. Utilizing the unique properties of AIE fluorogens (AIEgens), specific light-up probes have been constructed through functionalization with recognition elements, showing advantages such as low background interference, a high signal to noise ratio and superior photostability with activatable therapeutic effects. In this tutorial review, we summarize the recent progress in the development of specific AIEgen-based light-up bioprobes. Through illustration of their operation mechanisms and application examples, we hope to provide guidelines for the design of more advanced AIE sensing and imaging platforms with high selectivity, great sensitivity and wide adaptability to a broad range of biomedical applications.

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“…Li and Chen also described a new fluorescent “light‐up” probe 81 , in which a carboxylic ester group acted as the reactive site. [ 194 ] The probe itself showed negligible fluorescence in aqueous solution. Addition of carboxylesterase led to generation of a relatively hydrophobic tetraphenylethene derivative that further formed supramolecular microfibers by self‐assembling, resulting in strong fluorescence.…”

Section: Aiegens For Recognition Of Enzymesmentioning

confidence: 99%

Activity‐based smart AIEgens for detection, bioimaging, and therapeutics: Recent progress and outlook

et al. 2021

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Activity‐based approaches for designing AIEgens possess prominent advantages including high selectivity, sensitivity, and signal‐to‐noise ratio, and they have received more attention in recent years. Excellent activatable AIE probes have been reported for detecting toxic substances, imaging intracellular active molecules/biomolecules, as well as monitoring the activity of overexpressed enzymes in cancers. Moreover, the majority of activatable theranostic AIEgens can be specifically triggered in cancer cells and can kill these cells under light irradiation, while they have no distinct effect on normal cells, demonstrating satisfactory therapeutic selectivity that is superior to that of traditional chemotherapy. Thus, in this review, we systematically summarized the development of activatable AIE bioprobes in recent years from molecular design principles to biological applications. The challenges of activatable AIE probes and the corresponding solutions are described. We hope that the information provided in this review will facilitate the design of more activatable AIE probes to promote practical application of corresponding AIEgens.

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A Fluorogenic Probe with Aggregation‐Induced Emission Characteristics for Carboxylesterase Assay through Formation of Supramolecular Microfibers

Cited by 38 publications

References 52 publications

Aggregation‐Induced Emission: The Whole Is More Brilliant than the Parts

Aggregation‐Induced Emission: The Whole Is More Brilliant than the Parts

Specific light-up bioprobes based on AIEgen conjugates

Activity‐based smart AIEgens for detection, bioimaging, and therapeutics: Recent progress and outlook

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