A Fluorescent “Turn-off” Probe for the Determination of Curcumin Using Upconvert Luminescent Carbon Dots

Yu, Chenhong; Qi, Zhuang; Cui, Hanyue; Li, Li; Ding, Yaping; Lin, Jiaxin; Duan, Yingchun

doi:10.1007/s10895-020-02590-3

Cited by 15 publications

(3 citation statements)

References 37 publications

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“…From Figure a, it can be observed that the broad absorption of curcumin in the short wavelength region has considerable overlap with the emission spectrum of t-Se QDs. This clearly indicates that the decrease in fluorescence of t-Se QDs upon addition of curcumin is due to electron transfer, energy transfer, or the inner filter effect (IFE). ,− As curcumin is negatively charged, there will be no electrostatic interaction between selenium QDs and curcumin. , Thus, the fluorescence quenching observed in the mixture is not due to the electron transfer mechanism. UV–visible absorption spectra of t-Se QDs, Se–curcumin, and curcumin are shown in Figure S3, and no additional peak can be observed in the Se–curcumin spectrum.…”

Section: Resultsmentioning

confidence: 96%

Solid-State Fluorescent Selenium Quantum Dots by a Solvothermal-Assisted Sol–Gel Route for Curcumin Sensing

2021

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Toward the need for solid-state fluorescent quantum dots, resistant to self-quenching, we describe a solvothermal-assisted sol–gel method to synthesize Se quantum dots. Morphological and crystalline characterizations reveal that Se quantum dots (average size 3–8 nm) have a trigonal crystal structure. The presence of planar defects (dislocations, stacking faults, twins, and grain boundaries) suggests formation of Se nanocrystallites through aggregation-based crystal growth mechanisms. Under ultraviolet excitation, the quantum dots exhibit an excitation wavelength-dependent solid-state blue emission with an average lifetime of 1.96 ns. Depending on fluorescence quenching by curcumin, selenium quantum dots act as ideal candidates for inner filter effect-based curcumin sensing.

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Section: Resultsmentioning

confidence: 96%

Solid-State Fluorescent Selenium Quantum Dots by a Solvothermal-Assisted Sol–Gel Route for Curcumin Sensing

2021

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“…Curcumin has a broad fluorescent range, with maximum absorbance at 420 nm, and excitation-independent emission behavior with a maximum at 525 nm [31,32]. Fluorescent nanomaterials have been developed for curcumin detection [31], including semiconductor quantum dots [33], lanthanide upconversion nanoparticles [34], fluorescent metal nanoclusters [35,36], and carbon quantum dots [32,37,38]. Through fluorescence turn-off and/or ratiometric fluorescence response, nanomaterial fluorescence loss is used to quantify curcumin, with increasing curcumin concentration resulting in increased signal loss from the fluorescent nanomaterial [31].…”

Section: Discussionmentioning

confidence: 99%

Multiple Linear Regression Predictive Modeling of Colloidal and Fluorescence Stability of Theranostic Perfluorocarbon Nanoemulsions

Herneisey

Janjić

2023

Pharmaceutics

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Perfluorocarbon nanoemulsions (PFC-NEs) are widely used as theranostic nanoformulations with fluorescent dyes commonly incorporated for tracking PFC-NEs in tissues and in cells. Here, we demonstrate that PFC-NE fluorescence can be fully stabilized by controlling their composition and colloidal properties. A quality-by-design (QbD) approach was implemented to evaluate the impact of nanoemulsion composition on colloidal and fluorescence stability. A full factorial, 12-run design of experiments was used to study the impact of hydrocarbon concentration and perfluorocarbon type on nanoemulsion colloidal and fluorescence stability. PFC-NEs were produced with four unique PFCs: perfluorooctyl bromide (PFOB), perfluorodecalin (PFD), perfluoro(polyethylene glycol dimethyl ether) oxide (PFPE), and perfluoro-15-crown-5-ether (PCE). Multiple linear regression modeling (MLR) was used to predict nanoemulsion percent diameter change, polydispersity index (PDI), and percent fluorescence signal loss as a function of PFC type and hydrocarbon content. The optimized PFC-NE was loaded with curcumin, a known natural product with wide therapeutic potential. Through MLR-supported optimization, we identified a fluorescent PFC-NE with stable fluorescence that is unaffected by curcumin, which is known to interfere with fluorescent dyes. The presented work demonstrates the utility of MLR in the development and optimization of fluorescent and theranostic PFC nanoemulsions.

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“…22,23 However, as research on curcumin continues to increase, high-dose curcumin is likely to produce pro-oxidative activity on the DNA, resulting in decreased intercellular ATP levels and cell necrosis. 24 Thus, the quantitative detection of curcumin is particularly important for food safety and human health. Up to now, analytical methods for curcumin detection have mainly been high performance liquid chromatography, UV-Vis spectrometry, thin layer chromatography and fluorescence methods.…”

Section: Introductionmentioning

confidence: 99%

Preparation of yellow emissive nitrogen-doped carbon dots from o-phenylenediamine and their application in curcumin sensing

Dong

Bateer

et al. 2022

New J. Chem.

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A Fluorescent “Turn-off” Probe for the Determination of Curcumin Using Upconvert Luminescent Carbon Dots

Cited by 15 publications

References 37 publications

Solid-State Fluorescent Selenium Quantum Dots by a Solvothermal-Assisted Sol–Gel Route for Curcumin Sensing

Solid-State Fluorescent Selenium Quantum Dots by a Solvothermal-Assisted Sol–Gel Route for Curcumin Sensing

Multiple Linear Regression Predictive Modeling of Colloidal and Fluorescence Stability of Theranostic Perfluorocarbon Nanoemulsions

Preparation of yellow emissive nitrogen-doped carbon dots from o-phenylenediamine and their application in curcumin sensing

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