A fluorescent probe for the selective detection of creatinine in aqueous buffer applicable to human blood serum

Pal, Siddhartha; Lohar, Somenath; Mukherjee, Manjira; Chattopadhyay, Pabitra; Dhara, Koushik

doi:10.1039/c6cc07291g

Cited by 56 publications

(28 citation statements)

References 25 publications

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“…The detection limit (LOD) was calculated from the calibration curve based on the fluorescence enhancement at 572 nm ( Figure 6) by magnifying the lower concentration region of Cu 2+ ions, using the equation 3σ/S, where S is the slope of the line, and σ is the standard deviation of seven replicate measurements of the zero level. 46 LOD was found to be 30.75 nM. This indicates the efficiency of this probe towards the detection of Cu 2+ ions in the nanomolar range.…”

Section: Analytical Figure Of Meritmentioning

confidence: 72%

A new rhodamine based ‘turn-on’ $$\hbox {Cu}^{2+}$$ Cu 2 + ion selective chemosensor in aqueous system applicable in bioimaging

et al. 2017

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A new rhodamine-based Schiff base (L) has been synthesized and characterized by physicochemical and spectroscopic tools. This organic molecule selectively reacts with Cu 2+ ions with a remarkably significant optical change, which supports the development of a chemosensor for Cu 2+ ions as low as nanomolar level in aqueous medium. On the basis of the experimental work, the 'turn-on' colorimetric/fluorimetric spectroscopic change is due to Cu 2+ ion-assisted hydrolysis followed by spirolactam ring opening of the probe (L) in 20 mM HEPES buffer [pH 7.4; water/acetonitrile (9:1 v/v)]. The competitive ions do not affect the selectivity and specificity of the probe (L) in the detection of Cu 2+ ions. The cell imaging study using fluorescence microscope showed that this non-cytotoxic probe is useful to detect the distribution of Cu 2+ ions in AGS cells lines.

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Section: Analytical Figure Of Meritmentioning

confidence: 72%

A new rhodamine based ‘turn-on’ $$\hbox {Cu}^{2+}$$ Cu 2 + ion selective chemosensor in aqueous system applicable in bioimaging

et al. 2017

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“…In the context of development of fluorescent sensors for selective detection and imaging of trace level ions/molecules and the assessment of the target species through fluorescence turn‐on sensors in solution or in solid state, several photophysical (like PET, CHEF, ICT, FRET etc) processes have been considered enormously . There are a huge number of chemosensors in solution state in the literature compared to luminescent materials in solid states.…”

Section: Introductionmentioning

confidence: 99%

Aggregation Induced Emission Enhancement (AIEE) of Naphthalene‐ Appended Organic Moiety: An Al³⁺ Ion Selective Turn‐On Fluorescent Probe

et al. 2020

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An example of an aggregation‐induced emission enhancement (AIEE)‐active new naphthalene appended Schiff base (H2L) as an Al3+ ion selective fluorescent sensor has been successfully designed and synthesized. H2L showed turn‐on fluorescence at high concentration in DMF only, and at low concentration in DMF‐H2O mixtures having high water content (more than 20%). But at very low concentration of H2L and in DMF/H2O solutions with low water fraction (fw ≤ 20%), the fluorescence was turned ON in presence of Al3+ ions, which helps to detect Al3+ ions as low as 4.9×10−7 M with high selectivity in an DMF solution without any interference of other competitive metal ions. The fluorescence of H2L in different conditions and in solid state due to AIE effect has been established with the help of detailed spectroscopic studies, dynamic light scattering (DLS), scanning electron microscope (SEM), life time using time‐resolved photoluminescence and optical fluorescence microscope. The experimentally observed H‐type aggregation nature of the probe H2L has also been supported by the theoretical (DFT studies and TDDFT) studies. This probe (H2L) has also been employed for on‐site Al3+ ions detection in solid state.

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“…Therefore, development of selective and sensitive method for detecting HOCl is an utmost challenge to the researcher to look into the role of hypochlorite in biological systems. The fluorimetric method is considered as the most powerful technique due to its high sensitivity, fast response and simplicity of implementation and nondestructive advantages, compared to the traditional methods for the detection of hypochlorite, such as colorimetric, electrochemistry and chromatography …”

Section: Introductionmentioning

confidence: 99%

A Highly Selective Fluorescence Turn‐On Probe for the Sensing and Bioimaging of Hypochlorite Anion in Aqueous Media

et al. 2018

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A newly designed and structurally characterized 2,6-diformyl À4-methyl-phenol based moiety detects the hypochlorite ions as low as 75.9 nM selectively in DMSO-H 2 O (1:9, v/v) solution (100 mM HEPES buffer, pH 7.4) based on oxidation cleavage reaction of the thioacetal linkage. To establish this reaction based pathway in favor of sensing hypochlorite ions, the detailed spectroscopic studies have been carried out systematically supported by theoretical (DFT) studies. The efficacy of this non-cytotoxic probe has been checked by acquiring the fluorescence images of the distribution of the hypochlorite (ClO À ) ion in living cells.

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A fluorescent probe for the selective detection of creatinine in aqueous buffer applicable to human blood serum

Cited by 56 publications

References 25 publications

A new rhodamine based ‘turn-on’ $$\hbox {Cu}^{2+}$$ Cu 2 + ion selective chemosensor in aqueous system applicable in bioimaging

A new rhodamine based ‘turn-on’ $$\hbox {Cu}^{2+}$$ Cu 2 + ion selective chemosensor in aqueous system applicable in bioimaging

Aggregation Induced Emission Enhancement (AIEE) of Naphthalene‐ Appended Organic Moiety: An Al³⁺ Ion Selective Turn‐On Fluorescent Probe

A Highly Selective Fluorescence Turn‐On Probe for the Sensing and Bioimaging of Hypochlorite Anion in Aqueous Media

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A fluorescent probe for the selective detection of creatinine in aqueous buffer applicable to human blood serum

Cited by 56 publications

References 25 publications

A new rhodamine based ‘turn-on’ $$\hbox {Cu}^{2+}$$ Cu 2 + ion selective chemosensor in aqueous system applicable in bioimaging

A new rhodamine based ‘turn-on’ $$\hbox {Cu}^{2+}$$ Cu 2 + ion selective chemosensor in aqueous system applicable in bioimaging

Aggregation Induced Emission Enhancement (AIEE) of Naphthalene‐ Appended Organic Moiety: An Al3+ Ion Selective Turn‐On Fluorescent Probe

A Highly Selective Fluorescence Turn‐On Probe for the Sensing and Bioimaging of Hypochlorite Anion in Aqueous Media

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Aggregation Induced Emission Enhancement (AIEE) of Naphthalene‐ Appended Organic Moiety: An Al³⁺ Ion Selective Turn‐On Fluorescent Probe