2020
DOI: 10.1101/2020.07.07.187567
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A fluorescent l-2-hydroxyglutarate biosensor

Abstract: Abstractl-2-Hydroxyglutarate (l-2-HG) plays important roles in diverse physiological processes, such as carbon starvation response, tumorigenesis, and hypoxic adaptation. Despite its importance and intensively studied metabolism, regulation of l-2-HG metabolism remains poorly understood and a regulator specifically responded to l-2-HG has never been identified. Based on the genomic neighborhood analysis… Show more

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Cited by 5 publications
(5 citation statements)
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“…Additionally, monthly Meridional and Zonal wind (v &u), Relative humidity at higher and lower levels (850hPa & 200hPa), and vertical velocity were acquired from ERA 5, the fifth generation of the ECMWF. These datasets have high spatial and temporal resolution of 0.25o x 0.25o from 1992 to 2021 in horizontal grid spacing and the vertical layers of 137 in 1-h interval with more than 240 physical parameters available (Tang et al, 2023). The stations used for the observed datasets for Unguja Island include Kisauni (Zanzibar airport), Kizimbani agro-met, and Kilombero, while for Pemba Island the stations include Mkoani, Wete and Matangatuani.…”
Section: Data Setsmentioning
confidence: 99%
“…Additionally, monthly Meridional and Zonal wind (v &u), Relative humidity at higher and lower levels (850hPa & 200hPa), and vertical velocity were acquired from ERA 5, the fifth generation of the ECMWF. These datasets have high spatial and temporal resolution of 0.25o x 0.25o from 1992 to 2021 in horizontal grid spacing and the vertical layers of 137 in 1-h interval with more than 240 physical parameters available (Tang et al, 2023). The stations used for the observed datasets for Unguja Island include Kisauni (Zanzibar airport), Kizimbani agro-met, and Kilombero, while for Pemba Island the stations include Mkoani, Wete and Matangatuani.…”
Section: Data Setsmentioning
confidence: 99%
“…A sunken solar greenhouse was the original type of greenhouse used in China; its soil wall has been found to offer better thermal storage performance than reinforced concrete materials, and it is cheaper and better insulated than typical greenhouses (Zhang et al, 2010). A sunken heliostat is used to improve the indoor temperature and to create a suitable environment for plant growth.…”
Section: Introductionmentioning
confidence: 99%
“…TNLC is induced by a uniaxial load, so it is more convenient in practice. And the concept has been widely recognized [30][31][32][33][34][35][36][37]. The related research, however, is very limited.…”
Section: Introductionmentioning
confidence: 99%