A Fluorescence Study of New Angular Polycyclic Blue Light-Emitting pyrazolo[3,4-h][1,6]naphthyridine and their Interaction with Bovine Serum Albumin (BSA)

Abstract

The blue light-emitting pyrazolo[3,4-h][1,6]naphthyridines has been synthesized by Friedländer condensation of 4-amino-3-(4-phenyl)-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbaldehyde (o-aminoaldehyde) 1 with different cyclic ketones and 1,3-diketones. The synthesized angular polycyclic naphthyridine derivatives were studied for Semi-empirical, thermal, UV-vis and fluorescence spectroscopic properties on binding with bovin serum albumin (BSA). These fluorescence properties together with the neutral, hydrophobic nature of these compounds make these fluorophores good fluorescence probe for studying the micropolarity of proteins like BSA and in general the ligand-protein interactions. All of them displays bright absorption at 394 nm & emission in visible region (491 nm). Quantum yields of all synthesized compounds were calculated.

Synthesis and thermal, optical and morphological characterization of oligomeric polyamides based on thiophene and alkyl/phenyl‐silane moieties. Study of the electrospun deposition process

“…It can be seen that the emission maxima of the three samples are close to 450 nm in the blue region of the electromagnetic spectrum. The blue‐emitting materials are potential candidates for use in optoelectronics and optoelectronic devices such as tunable lasers and amplifers, optical fibers and electroluminescent devices …”