A fluorescence optosensor for analyzing naphazoline in pharmaceutical preparations

Contribution to Automation for Determination of Drugs Based on Flow-Through Optosensors

“…The added economy and simplicity and relative flexibility have made it the officially recommended choice for determining the purity of many drugs in pharmaceutical Downloaded by [Uppsala universitetsbibliotek] at 23:25 06 October 2014 Table 1 Monoparameter FTOs with photometric detection Table 2 Multiparameter FTOs with photometric detection Table 3 Monoparameter FTOs with fluorimetric detection Table 4 Multiparameter FTOs with fluorimetric detection preparations. The intrinsic fluorescence of the analyte has been used for the determination of several compounds, such as naphazoline (64) or propanolol (65) using commercial solid supports, tetracyclines using a modified cyclodextrin based sensor (66), and digoxin by means of an MIP fluorosensor (67). Because there are a small number of compounds that exhibit native fluorescence, derivatization reactions have been employed to increase the number of applications.…”

State-of-the-Art of (Bio)Chemical Sensor Developments in Analytical Spanish Groups

“…The optosensor proposed was satisfactorily applied to the determination of the considered PAHs in water samples in presence of the other 12 EPA-PAHs [267]. New papers present the development of a single flow-through phosphorescence optosensor based on a nonionic resin solid support (Amberlite XAD 7) for determination of pesticide N-1-naphthylphthlamic acid (NAP) [268] and simultaneous determination of NAP and its metabolite 1-naphthylamine (NNA) [269]. This group describes two luminescence methods based on a flow-through optical sensor to determine 2-naphthoxyacetic acid.…”

The development of a MIP-optosensor for the detection of monoamine naphthalenes in drinking water

“…The optosensing manifold used for the luminescence measurements was similar to others previously described by our research group (Fernández-Sánchez et al, 2004;Casado Terrones et al, 2005). The polymer particles were packed in a conventional luminescence flow-through quartz cell (Hellma, model 176.052-QS) of 1.5 mm light path.…”

“…The combination of flow-injection with detection on optically active surfaces packed in a flow-through cell (optosensor) (Fernández-Sánchez et al, 2003 has proved to offer important advantages due to its high sensitivity and selectivity, precision, simplicity, speed and low cost (Casado Terrones et al, 2005). Further developments of these optosensing techniques have shortened analysis time considerably and reduced costs for routine environmental control.…”