A flexible porous chiral auxetic tracheal stent with ciliated epithelium

Liu, Jiapeng; Yao, Xinhua; Wang, Zhenwei; Ye, Jian; Luan, Congcong; He, Yong; Lin, Hui; Fu, Jianzhong

doi:10.1016/j.actbio.2021.01.044

Cited by 38 publications

(22 citation statements)

References 55 publications

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“…As reported in very recent studies, [ 50,51 ] engineering a tracheal stent that displays micrometric porosity is an additional, desired attribute. This feature is especially important in the context of tracheal Tissue Engineering, where the stent performs also as a scaffold for autologous tissue regeneration.…”

Section: Resultsmentioning

confidence: 99%

A Personalized Multifunctional 3D Printed Shape Memory‐Displaying, Drug Releasing Tracheal Stent

Maity

Mansour

Chakraborty

et al. 2021

Adv Funct Materials

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The ability to engineer custom-made medical devices and to implant them minimally invasively are two important trends in modern surgery. The personalization of the device is achieved by 3D printing it, while the capacity to deploy it minimally invasively harnesses the shape memory behavior displayed by the inks used. This study introduces a 3D printed, shape memorydisplaying tracheal stent based on novel, flexible photo-polymerizable inks comprising polypropylene glycol/polycaprolactone triblocks. This research introduces the in situ welding strategy, whereby thin and flexible layers of the stent are separately printed, sequentially deployed, and then welded together at the tracheal site. By doing so, the insertion profile of the device is dramatically reduced and its flexibility largely increased. Porous stents are 3D printed seeking to prevent mucus plugging. By combining more than one ink, their properties are further fine-tuned. Polyethylene glycol chains are covalently bonded to the stent surface to minimize biofilm formation, an important drawback of current tracheal stents. The in vitro cell viability and cell adhesion behavior of the treated surfaces reveal their compatibility and anti-adhesive behavior. In order to prevent implant-related infections, ciprofloxacin is added to the ink, and released in vitro over time, rendering the stent with antibacterial activity.

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Section: Resultsmentioning

confidence: 99%

A Personalized Multifunctional 3D Printed Shape Memory‐Displaying, Drug Releasing Tracheal Stent

Maity

Mansour

Chakraborty

et al. 2021

Adv Funct Materials

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show abstract

“…The authors suggest that the cylindrical chiral auxetic hybrid scaffold demonstrates good auxetic properties that can increase the cross-sectional area, thereby improving ventilation and the antimigration strength of the stent. In addition, the stent can solve the problem of mucus blockage, as NHBE cells are able to successfully differentiate into ciliated pseudostratified columnar epithelium on the inner wall of the stent [14].…”

Section: Stentsmentioning

confidence: 99%

Auxetic Metamaterials for Biomedical Devices: Current Situation, Main Challenges, and Research Trends

et al. 2022

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Auxetic metamaterials are characterized by a negative Poisson ratio (NPR) and display an unexpected property of lateral expansion when stretched and densification when compressed. Auxetic properties can be achieved by designing special microstructures, hence their classification as metamaterials, and can be manufactured with varied raw materials and methods. Since work in this field began, auxetics have been considered for different biomedical applications, as some biological tissues have auxetic-like behaviour due to their lightweight structure and morphing properties, which makes auxetics ideal for interacting with the human body. This research study is developed with the aim of presenting an updated overview of auxetic metamaterials for biomedical devices. It stands out for providing a comprehensive view of medical applications for auxetics, including a focus on prosthetics, orthotics, ergonomic appliances, performance enhancement devices, in vitro medical devices for interacting with cells, and advanced medicinal clinical products, especially tissue engineering scaffolds with living cells. Innovative design and simulation approaches for the engineering of auxetic-based products are covered, and the relevant manufacturing technologies for prototyping and producing auxetics are analysed, taking into consideration those capable of processing biomaterials and enabling multi-scale and multi-material auxetics. An engineering design rational for auxetics-based medical devices is presented with integrative purposes. Finally, key research, development and expected technological breakthroughs are discussed.

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“…[51,261,262] 3) The applications in giant machinery, such as, aerospace, including smart load-bearing and anti-impact structures, [1,27,46,181,263] morphing airfoils, [264] acoustic stealth cloaks, [48,[225][226][227] elastic mechanical cloaks, [48] reconfigurable antenna, [24,180,265,266] terahertz metadevices, [267] electromagnetic stealth system. [268][269][270] 4) The applications in biomedicine include electronic skin, [258,[271][272][273][274][275] tissue engineering, [192,194,[276][277][278][279][280] vascular stents, [54,136,[281][282][283] drug delivery carriers. [136,210,284,285] From the above discussion, the rich functions and application value of AMMs have brought great convenience to human production and life.…”

Section: Practical Applications Of Active Mechanical Metamaterialsmentioning

confidence: 99%

“…[ 51 , 261 , 262 ] 3) The applications in giant machinery, such as, aerospace, including smart load‐bearing and anti‐impact structures, [ 1 , 27 , 46 , 181 , 263 ] morphing airfoils, [ 264 ] acoustic stealth cloaks, [ 48 , 225 , 226 , 227 ] elastic mechanical cloaks, [ 48 ] reconfigurable antenna, [ 24 , 180 , 265 , 266 ] terahertz metadevices, [ 267 ] electromagnetic stealth system. [ 268 , 269 , 270 ] 4) The applications in biomedicine include electronic skin, [ 258 , 271 , 272 , 273 , 274 , 275 ] tissue engineering, [ 192 , 194 , 276 , 277 , 278 , 279 , 280 ] vascular stents, [ 54 , 136 , 281 , 282 , 283 ] drug delivery carriers. [ 136 , 210 , 284 ,…”

Section: Functions and Practical Applications Of Active Mechanical Metamaterialsmentioning

confidence: 99%

Recent Progress in Active Mechanical Metamaterials and Construction Principles

et al. 2021

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Active mechanical metamaterials (AMMs) (or smart mechanical metamaterials) that combine the configurations of mechanical metamaterials and the active control of stimuli-responsive materials have been widely investigated in recent decades. The elaborate artificial microstructures of mechanical metamaterials and the stimulus response characteristics of smart materials both contribute to AMMs, making them achieve excellent properties beyond the conventional metamaterials. The micro and macro structures of the AMMs are designed based on structural construction principles such as, phase transition, strain mismatch, and mechanical instability. Considering the controllability and efficiency of the stimuli-responsive materials, physical fields such as, the temperature, chemicals, light, electric current, magnetic field, and pressure have been adopted as the external stimuli in practice. In this paper, the frontier works and the latest progress in AMMs from the aspects of the mechanics and materials are reviewed. The functions and engineering applications of the AMMs are also discussed. Finally, existing issues and future perspectives in this field are briefly described. This review is expected to provide the basis and inspiration for the follow-up research on AMMs.

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A flexible porous chiral auxetic tracheal stent with ciliated epithelium

Cited by 38 publications

References 55 publications

A Personalized Multifunctional 3D Printed Shape Memory‐Displaying, Drug Releasing Tracheal Stent

A Personalized Multifunctional 3D Printed Shape Memory‐Displaying, Drug Releasing Tracheal Stent

Auxetic Metamaterials for Biomedical Devices: Current Situation, Main Challenges, and Research Trends

Recent Progress in Active Mechanical Metamaterials and Construction Principles

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