A flexible polymersome system with tunable morphology and release profiles for efficient intracellular delivery

Croitoru-Sadger, Tsuf; Leichtmann‐Bardoogo, Yael; Mizrahi, Boaz

doi:10.1016/j.ijpharm.2016.04.062

Cited by 9 publications

(7 citation statements)

References 47 publications

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“…Cells showed remarkable viability (as a percentage, relative to unexposed cells) above 80%, suggesting biocompatibility with fibroblast cells. These results are in agreement with our previous results with star-PEG–PCL of similar and shorter PCL segments . While PEG is nontoxic polymer, PCL is biocompatible, biodegradable, and nontoxic polyester .…”

Section: Results and Discussionsupporting

confidence: 93%

“…Gold nanoparticles are widely used for drug delivery purposes, since they have a unique property of absorbing light and in response release heat. − Our structure motif is based on the ability of GNS to absorb light in the NIR window and in response efficiently emit heat that diffuses to the surrounding medium. − To this end, we have developed a straightforward synthetic scheme (Scheme ) to produce a series of multiarmed PEG–PCL (star-PEG–PCL) copolymers with tailored melting points, which can be governed by the length of the PCL segments. The effect of molecular weight on polymers’ melting points is pronounced in multiarmed structures in comparison to linear polymers of the same size and composition. , Also, it has been suggested that star-shaped copolymers have lower melting points than linear copolymers of similar composition and molecular weight. ,, Applying these copolymers could potentially decrease the risk of overheating, and damaging surrounding tissue and could also be exploited for on-demand healing and release of guest molecules (Movie S1).…”

Section: Introductionmentioning

confidence: 99%

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Near-Infrared Light Induced Phase Transition of Biodegradable Composites for On-Demand Healing and Drug Release

Shagan

Croitoru-Sadger

Corem-Salkmon

et al. 2018

ACS Appl. Mater. Interfaces

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Light responsive materials play an important role in many biomedical applications. Despite the great potential, commonly available systems are limited by their toxicity and lack of biodegradability. Here, an efficient light triggered system from safe, biodegradable star-poly(ethylene glycol) (star-PEG) and poly(ε-caprolactone) (PCL) with varying melting points controlled by the length of the CL segments is described. When incorporated with gold nanoshells (GNS) and exposed to near-infrared (NIR) irradiation, matrices temporarily disengage, thus allowing efficient on-demand healing and drug release. The responsiveness of this system to light, with its tailorable physical and healing properties, biocompatibility, biodegradability, and the capability to incorporate drugs and on-demand drug release are all desirable traits for numerous clinical applications.

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Section: Results and Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Near-Infrared Light Induced Phase Transition of Biodegradable Composites for On-Demand Healing and Drug Release

Shagan

Croitoru-Sadger

Corem-Salkmon

et al. 2018

ACS Appl. Mater. Interfaces

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“…This correlation between CMC value and the length of the hydrophobic segment is in accord with results published by our lab on other amphiphilic copolymers with a fixed PEG segment. [14] A similar relationship between the length of the hydrophobic segment and CMC values was observed for other four-armed PEG-PLGA copolymers. These trends were explaind by the negative free energy of micellization that larger hydrophobic segments possess.…”

Section: Resultssupporting

confidence: 69%

“…[ 13 ] These systems, however, are usually not designed to contain hydrophobic drugs and their release of hydrophilic drugs is very fast, typically within a few hours. [ 14 ]…”

Section: Introductionmentioning

confidence: 99%

“…[13] These systems, however, are usually not designed to contain hydrophobic drugs and their release of hydrophilic drugs is very fast, typically within a few hours. [14] Here, we present a new liquid copolymer/drug mixture that self-assembles after being injected into the body to form a particulate delivery system ( Figure 1). The structure motif of this system is based on a neat (solvent-free) yet liquid copolymer that can be mixed with a hydrophilic or hydrophobic drug before injection.…”

Section: Introductionmentioning

confidence: 99%

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Injectable Drug Delivery System Based on In Situ Self‐Assembly of Liquid Star Polyethylene Glycol–Poly(lactic‐co‐glycolic acid)

Eylon

Shagan

Shabtay-Orbach

et al. 2021

Advanced NanoBiomed Research

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Particulate systems are widely used in biomedical applications, yet current systems are limited by their stability, complicated production processes, and the use of toxic excipients and cosolvents. Here, a new concept for an injectable nanocarrier system based on the in situ self‐assembled star polyethylene glycol (PEG)– poly(lactic‐co‐glycolic acid) (PLGA)/drug mixture is presented. The new injectable material is based on a neat (solvent‐free) liquid copolymer that self‐assembles after it is injected along with the drug to form a particulate delivery system. The nanocarriers’ formation rate and encapsulation capabilities of hydrophobic drugs can be fine‐tuned by changing the molecular weight of the PLGA segment. Furthermore, the starPEG–PLGA‐based system demonstrates potential as a drug carrier for hydrophobic drugs and shows biocompatibility with cell line culture.

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Polymersomes: Beyond Basics‐Synthesis, Stimuli Response and Biomedical Applications

Athulya,

Varughese,

Kumar

2024

ChemistrySelect

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Polymersomes, also known as polymeric vesicles, have high potential in the field of biomedicines due to their high stability and ability to carry hydrophilic and hydrophobic materials to the targeted sites without any loss. The self‐assembly of amphiphilic block copolymers into hollow spherical structures, known as polymersomes, has opened up new frontiers in biomedicine and other bio‐related applications. These structures harness the unique properties of biopolymers such as polyethylene glycol (PEG), polycaprolactone (PCL), and polypeptides, which contribute to their biocompatibility and functionality. The need for efficient materials for applications in the field of targeted drug delivery, theranostics, and bio‐imaging is increasing day by day so that scientists are in search of efficient polymersomes by making modifications in their structures. This review outlines various block copolymers from which polymersomes can be made, the types of polymersomes, the ways to prepare the materials along with the biomedical applications that the polymersomes can be opted for. Here we discuss about self‐assembly techniques like solvent switch, microfluid, pH tuning and polymerization induced self‐assembly. The present paper provides an overview of stimuli‐responsive polymersomes. Towards the end of the review, several applications of polymersomes are covered, such as drug administration, imaging, theranostics, and usage as nanoreactors.

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A flexible polymersome system with tunable morphology and release profiles for efficient intracellular delivery

Cited by 9 publications

References 47 publications

Near-Infrared Light Induced Phase Transition of Biodegradable Composites for On-Demand Healing and Drug Release

Near-Infrared Light Induced Phase Transition of Biodegradable Composites for On-Demand Healing and Drug Release

Injectable Drug Delivery System Based on In Situ Self‐Assembly of Liquid Star Polyethylene Glycol–Poly(lactic‐co‐glycolic acid)

Polymersomes: Beyond Basics‐Synthesis, Stimuli Response and Biomedical Applications

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