A flexible loop-type flow modulator for comprehensive two-dimensional gas chromatography

Tranchida, Peter Q.; Purcaro, Giorgia; Visco, Alessandro; Conte, L. S.; Dugo, Paola; Dawes, Peter; Mondello, Luigi

doi:10.1016/j.chroma.2010.11.082

Cited by 35 publications

(9 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With respect to previous work, the problems related to sensitivity have been reduced: circa 80% of the flow was directed to vent, against 95% [15]. Such an improvement was attained by a more fine regulation of the flushing flow, which must be at least 20 mL/min.…”

Section: Discussionmentioning

confidence: 79%

“…Although the design of the flow modulator has been previously reported [15], it will be herein briefly described for the benefit of the reader (Fig. 1).…”

Section: Methods Developmentmentioning

confidence: 99%

“…In recent research, a novel FM device was developed, and then positively evaluated in GC × GC-FID applications, on an essential oil and diesel sample [15]. In the former application, a chiral 20 m × 0.1 mm ID capillary was used as first dimension, while a polyethylene glycol 2.5 m × 0.25 mm ID one was used as the second one.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A flow-modulated comprehensive gas chromatography–mass spectrometry method for the analysis of fatty acid profiles in marine and biological samples

Tranchida

Franchina

Dugo

et al. 2012

Journal of Chromatography A

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 79%

“…Although the design of the flow modulator has been previously reported [15], it will be herein briefly described for the benefit of the reader (Fig. 1).…”

Section: Methods Developmentmentioning

confidence: 99%

See 1 more Smart Citation

A flow-modulated comprehensive gas chromatography–mass spectrometry method for the analysis of fatty acid profiles in marine and biological samples

Tranchida

Franchina

Dugo

et al. 2012

Journal of Chromatography A

Self Cite

View full text Add to dashboard Cite

“…The modulation period was 4500 ms, with a 100 ms flushing pulse. A detailed description of the flow modulator herein employed can be found in the literature .…”

Section: Methodsmentioning

confidence: 99%

A direct sensitivity comparison between flow‐modulated comprehensive 2D and 1D GC in untargeted and targeted MS‐based experiments

Tranchida

Franchina

Zoccali

et al. 2013

J of Separation Science

Self Cite

View full text Add to dashboard Cite

The present contribution is focused on the measurement of the analytical sensitivity attained in untargeted/targeted MS/MS experiments, performed using flow-modulator comprehensive 2D and 1D GC. The comprehensive 2D experiment was performed by diverting part of the high flow (circa 80%) to flush the accumulation loop (about 28 mL/min) to waste, to reduce the gas flow entering the ion source. 1D analyses were performed through: (i) unmodulated and (ii) single column applications. An equivalent temperature program was applied in the modulated and unmodulated analyses, while a faster one was employed in the single column one. In all application types, the (same) triple quadrupole instrument was operated in the full-scan and multiple reaction monitoring modes. A genuine sweet orange oil and the same sample spiked with 20 phytosanitary compounds were employed to reach the research objective. The results highlight the problems related to the flow modulation-MS combination. Specifically, it was found that sensitivity was on average three to four times higher in unmodulated and optimized single-column applications.

show abstract

“…Chromatographic platforms with cryofocusing modulators were also applied by other authors (Adahchour et al, 2003;Chin et al, 2011;Bueno et al, 2014). A less complicated solution than cryo-focusing modulation applied in comprehensive GCxGC is a simple flow modulation (Tranchida et al, 2011;Manzano et al, 2014). Another technique, which is a variation of two-dimensional chromatography, is heart-cutting multi-dimensional gas chromatography equipped with a Deans switch, (H/C MDGC).…”

Section: Volatile Compounds Analysis By Gas Chromatography and Samplementioning

confidence: 99%

Sense of smell and volatile aroma compounds and their role in the evaluation of the quality of products of animal origin – a review

Gąsior

Wojtycza

2016

Annals of Animal Science

View full text Add to dashboard Cite

The aim of this article is to examine how the sense of smell and aroma compounds influence the quality of food of animal origin, and to review gas chromatography-olfactometry methods of volatile substances analysis that can help to promote regional animal products. Smell and smell-inducing compounds play an important role in human life. people have made use of aromatic herbs and spices for ages. The classification of smells was developed by, among others, Aristotle, Linnaeus, Zwaardemaker, as well as amoore, the creator of the stereochemical theory of olfaction. Smell is also of exceptional importance in a consumer's evaluation of food quality. achievements in the area of chromatography, mass spectrometry and olfactometry have contributed to the development of tests for the content of volatile compounds in food materials, e.g. milk, cheese or meat. analysis of these compounds is more and more often applied to regional products that are commonly characterised by different olfactory properties. the study's results of raw meat of different animal species show that nutria meat and mutton differ the most from others. apart from genetic factors, meat composition depends on feeding method, quality and type of fodder, method of cutting, meat seasoning, ph and temperature of processing. chromatographic and olfactometric tests on animal products, in conjunction with chemometrics, can contribute to the development of reliable characteristics and help to identify the products' origin. these tests are becoming an inseparable part of the policy of promotion of regional products with specific taste and olfactory properties.

show abstract

A flexible loop-type flow modulator for comprehensive two-dimensional gas chromatography

Cited by 35 publications

References 10 publications

A flow-modulated comprehensive gas chromatography–mass spectrometry method for the analysis of fatty acid profiles in marine and biological samples

A flow-modulated comprehensive gas chromatography–mass spectrometry method for the analysis of fatty acid profiles in marine and biological samples

A direct sensitivity comparison between flow‐modulated comprehensive 2D and 1D GC in untargeted and targeted MS‐based experiments

Sense of smell and volatile aroma compounds and their role in the evaluation of the quality of products of animal origin – a review

Contact Info

Product

Resources

About