A flexible, light-weight multichannel sieve electrode with integrated cables for interfacing regenerating peripheral nerves

Stieglitz, Thomas; Beutel, H.; Meyer, J.-U.

doi:10.1016/s0924-4247(97)01494-5

Cited by 119 publications

(53 citation statements)

References 4 publications

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“…14,15 The PI2611 polyimide has a low water absorption of only 0.5%, and previous studies have shown that it is mechanically stable after long in vitro and in vivo testing and also that it is biocompatible. 4,15 The electrodes consist of a round sieve interface (2 mm in diameter), a narrow ribbon cable (1 mm wide, 21 mm long), and an ending connector (2 × 3 mm).…”

Section: Sieve Electrode Implantmentioning

confidence: 99%

“…Because of its more adaptive physical and chemical characteristics, polyimide neural electrodes have been tried out recently. 4,13,14 Polyimide allows the making of a higher number of holes than do silicon chips of the same total area, and it also can be micromachined in a variety of designs suitable for implantation in different-sized nerves and to accommodate different anatomical regions. Its biocompatibility has been tested [15][16][17] and only mild fibrous reaction was shown after in vivo implantation.…”

Section: Introductionmentioning

confidence: 99%

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Morphologic and functional evaluation of peripheral nerve fibers regenerated through polyimide sieve electrodes over long‐term implantation

Ceballos

Valero‐Cabré

Valderrama

et al. 2002

J. Biomed. Mater. Res.

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We evaluated by morphologic and functional analysis the regeneration of peripheral nerve fibers through polyimide regenerative-type electrodes over long-term implantation. Polyimide sieve electrodes were placed in silicone chambers and implanted between the severed ends of the sciatic nerve in rats. The sieve part had 281 round via holes of 40 microm in diameter, with nine integrated recording-stimulating electrodes arranged around the via holes. The degree of axonal regeneration was examined at 2, 7, and 12 months postimplantation (mpi). Regeneration was successful in 12 of the 13 animals implanted. Reinnervation of distal muscle and nerves increased with time, reaching a plateau about 7 mpi. The number of myelinated fibers increased from 2 to 7 months, at which time it was similar to control values. With time the myelinated fibers matured, with significant increases in axon diameter and myelin thickness. Only 0.6% of the regenerated axons showed evidence of compression near the implanted electrode. The majority of the myelinated fibers that crossed the via holes and had been regenerated through the distal nerve had a normal appearance. Sieve electrodes were useful for nerve stimulation at postimplantation. Stimulation through different active electrodes excited nerve bundles, evoking compound muscle action potentials of varying shape and amplitude, indicative of selective axonal stimulation.

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Section: Sieve Electrode Implantmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Morphologic and functional evaluation of peripheral nerve fibers regenerated through polyimide sieve electrodes over long‐term implantation

Ceballos

Valero‐Cabré

Valderrama

et al. 2002

J. Biomed. Mater. Res.

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“…The amplified signals are transferred to the units which are controlling the prostheses as shown in figure 8. For more details about the chip, please refer to [38].…”

Section: The Neurosensormentioning

confidence: 99%

Application of Artificial Neural Networks for Different Engineering Problems

Bogdan¹

1999

SOFSEM’99: Theory and Practice of Informatics

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This paper presents some applications of data and signal processing using artificial neural nets (ANNs) which have been investigated at the University of Tübingen. The applications covering a wide range of different interesting domains: color restoration, gas sensing systems, internet information search and delivery, online quality control and nerve signal processing. In order to achieve the requirements of each application supervised learning as well as unsupervised learning artificial neural nets have been used. The paper presents each application in detail and describes the problems which have been solved using artificial neural nets.

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“…Flexible cables for data transmission from chronically implanted extracellular probes were developed (Cheng et al 2013). In order to obtain electrical connection with peripheral nerves, polymer-based sieve (Stieglitz et al 1997), cuff (Rodriguez et al 2000) and transverse (Boretius et al 2010) probes are available. Microfabricated polymer structures are commonly applied for electrocorticography (ECoG) as well (Yeager et al 2008;Myllymaa et al 2009;Rubehn et al 2009;Ochoa et al 2013), which is a widely used method for the localization of epileptogenic zones (Keene et al 2000).…”

Section: Introductionmentioning

confidence: 99%

A polymer-based spiky microelectrode array for electrocorticography

et al. 2014

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The advanced technology of microelectromechanical systems (MEMS) makes possible precise and reproducible construction of various microelectrode arrays (MEAs) with patterns of high spatial density. Polymer-based MEMS devices are gaining increasing attention in the field of electrophysiology, since they can be used to form flexible, yet reliable electrical interfaces with the central and the peripheral nervous system. In this paper we present a novel MEA, designed for obtaining neural signals, with a polyimide (PI) -platinum (Pt) -SU-8 layer structure. Electrodes with special, arrow-like shapes were formed in a single row, enabling slight penetration into the tissue. The applied process flow allowed reproducible batch fabrication of the devices with high yield. In vitro characterization of the electrode arrays was performed with electrochemical impedance spectroscopy (EIS) in lactated Ringer's solution. Functional tests were carried out by performing acute recordings on rat neocortex. The devices have proven to be convenient tools for acute in vivo electrocorticography.

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A flexible, light-weight multichannel sieve electrode with integrated cables for interfacing regenerating peripheral nerves

Cited by 119 publications

References 4 publications

Morphologic and functional evaluation of peripheral nerve fibers regenerated through polyimide sieve electrodes over long‐term implantation

Morphologic and functional evaluation of peripheral nerve fibers regenerated through polyimide sieve electrodes over long‐term implantation

Application of Artificial Neural Networks for Different Engineering Problems

A polymer-based spiky microelectrode array for electrocorticography

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