A flexible hydrophilic-modified graphene microprobe for neural and cardiac recording

Chen, Chang-Hsiao; Lin, Cheng‐Te; Hsu, Wen-Jing; Chang, Y. C.; Yeh, Shih-Rung; Li, Lain‐Jong; Yao, Da‐Jeng

doi:10.1016/j.nano.2012.12.004

Cited by 89 publications

(69 citation statements)

References 10 publications

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“…[298] Graphene has been used in cellular interfaces and electrical recording due to its appealing physicochemical properties. [297,299,306,317] Hess et al developed arrays of graphene-based solution-gated field-effect transistors (G-SGFETs) for the extracellular detection of electrical signals from cardiomyocyte-like HL-1 cells.…”

Section: Electroactive Nanomaterials For Electrode-tissue Interfacesmentioning

confidence: 99%

“…In order to reduce the mechanical mismatch between the graphene and the surrounding tissue and enhance the electrical conductivity of the hydrophobic graphene, [298,299] integrated flexible graphene electrodes have been developed. [297,328] Chen et al designed a flexible, hydrophilic graphene microprobe to measure action potentials from the axons located in the abdominal nerve cord of crayfish (Figure 12f).…”

Section: Electroactive Nanomaterials For Electrode-tissue Interfacesmentioning

confidence: 99%

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A Review of Organic and Inorganic Biomaterials for Neural Interfaces

et al. 2014

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Recent advances in nanotechnology have generated wide interest in applying nanomaterials for neural prostheses. An ideal neural interface should create seamless integration into the nervous system and performs reliably for long periods of time. As a result, many nanoscale materials not originally developed for neural interfaces become attractive candidates to detect neural signals and stimulate neurons. In this comprehensive review, an overview of state-of-the-art microelectrode technologies provided first, with focus on the material properties of these microdevices. The advancements in electro active nanomaterials are then reviewed, including conducting polymers, carbon nanotubes, graphene, silicon nanowires, and hybrid organic-inorganic nanomaterials, for neural recording, stimulation, and growth. Finally, technical and scientific challenges are discussed regarding biocompatibility, mechanical mismatch, and electrical properties faced by these nanomaterials for the development of long-lasting functional neural interfaces.

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Section: Electroactive Nanomaterials For Electrode-tissue Interfacesmentioning

confidence: 99%

Section: Electroactive Nanomaterials For Electrode-tissue Interfacesmentioning

confidence: 99%

A Review of Organic and Inorganic Biomaterials for Neural Interfaces

et al. 2014

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“…Graphene has excellent electrical and thermal conductivity, displays high stiffness while being elastic which make it a favorable material for flexible electronics and wearable sensors [21][22][23]. To harness the unique properties of graphene and the advantages of textile-based materials in biosensing, we show the merger of the two through a simple and scalable fabrication process whereby M a n u s c r i p t 2 conductive textiles are formed using graphene as a cladding layer.…”

Section: Introductionmentioning

confidence: 99%

Graphene-clad textile electrodes for electrocardiogram monitoring

Yapıcı

Alkhidir

Samad

et al. 2015

Sensors and Actuators B: Chemical

196

129

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“…The biocompatibility of graphene can also be improved by appropriate physical treatments instead of being coated with other nonconducting biomaterials. Chen et al [52] reported that graphene deposited electrodes on a flexible microprobe could be used as a retina prosthesis electrode. They treated the graphene surface with steam plasma in order to make the electrode hydrophilic as well as biocompatible.…”

Section: Applications For Drug Deliverymentioning

confidence: 99%

Graphene: an emerging material for biological tissue engineering

Lee¹,

Kim²,

Shim³

2013

Carbon letters

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Graphene, a carbon crystal sheet of molecular thickness, shows diverse and exceptional properties ranging from electrical and thermal conductivities, to optical and mechanical qualities. Thus, its potential applications include not only physicochemical materials but also extends to biological uses. Here, we review recent experimental studies about graphene for such bioapplications. As a prerequisite to the search to determine the potential of graphene for bioapplications, the essential qualities of graphene that support biocompatibility, were briefly summarized. Then, direct examples of tissue regeneration and tissue engineering utilizing graphenes, were discussed, including uses for cell scaffolds, cell modulating interfaces, drug delivery, and neural interfaces.

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A flexible hydrophilic-modified graphene microprobe for neural and cardiac recording

Cited by 89 publications

References 10 publications

A Review of Organic and Inorganic Biomaterials for Neural Interfaces

A Review of Organic and Inorganic Biomaterials for Neural Interfaces

Graphene-clad textile electrodes for electrocardiogram monitoring

Graphene: an emerging material for biological tissue engineering

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