A flavonoid glycoside isolated from Smilax china L. rhizome in vitro anticancer effects on human cancer cell lines

Li, Yuanli; Guoping, Gan; Zhang, Huizhan; H, Wu; Li, Changlong; Huang, Yongping; Liu, Yanwen; Liu, Jianwen

doi:10.1016/j.jep.2007.05.016

Cited by 132 publications

(74 citation statements)

References 38 publications

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“…Jacaranone has been investigated as a potential anti-cancer agent (Loizzo et al 2007). Flavanoids in general caused a significant extension of life span in cancer-susceptible mice (Butelli et al 2008), while kaempferol in particular demonstrated a cytotoxic activity on human cancer cell lines (Daniela et al 2007;Li et al 2007). A tomato with increased amounts of flavanoids, whereby kaempferol glycoside accounted for 60% of this increase, has already been engineered (Le Gall et al 2003).…”

Section: Discussionmentioning

confidence: 99%

NMR Metabolomics of Thrips (Frankliniella occidentalis) Resistance in Senecio Hybrids

et al. 2009

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Western flower thrips (Frankliniella occidentalis) has become a key insect pest of agricultural and horticultural crops worldwide. Little is known about host plant resistance to thrips. In this study, we investigated thrips resistance in F 2 hybrids of Senecio jacobaea and Senecio aquaticus. We identified thrips-resistant hybrids applying three different bioassays. Subsequently, we compared the metabolomic profiles of these hybrids applying nuclear magnetic resonance spectroscopy (NMR). The new developments of NMR facilitate a wide range coverage of the metabolome. This makes NMR especially suitable if there is no a priori knowledge of the compounds related to herbivore resistance and allows a holistic approach analyzing different chemical compounds simultaneously. We show that the metabolomes of thrips-resistant and -susceptible hybrids differed considerably. Thrips-resistant hybrids contained higher amounts of the pyrrolizidine alkaloids (PA), jacobine, and jaconine, especially in younger leaves.Also, a flavanoid, kaempferol glucoside, accumulated in the resistant plants. Both PAs and kaempferol are known for their inhibitory effect on herbivores. In resistant and susceptible F 2 hybrids, young leaves showed less thrips damage than old leaves. Consistent with the optimal plant defense theory, young leaves contained increased levels of primary metabolites such as sucrose, raffinose, and stachyose, but also accumulated jacaranone as a secondary plant defense compound. Our results prove NMR as a promising tool to identify different metabolites involved in herbivore resistance. It constitutes a significant advance in the study of plant-insect relationships, providing key information on the implementation of herbivore resistance breeding strategies in plants.

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Section: Discussionmentioning

confidence: 99%

NMR Metabolomics of Thrips (Frankliniella occidentalis) Resistance in Senecio Hybrids

et al. 2009

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“…The cytotoxic activities could be due to the presence of apoptotic and anti-proliferative flavonoids and other phenolics in the extract [26,27]. A cytotoxic biflavonoid compound was previously isolated from the same extract, which exhibited anticancer activity against breast cancer [7].…”

Section: Cytotoxic Activitymentioning

confidence: 99%

Hepatoprotective, Antihyperglycemic and Cytotoxic Activities of Jacaranda acutifolia Leaf Extract

Jamie¹,

Alshami²,

Maliabari³

et al. 2017

Med Aromat Plants

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Objective: Leaves methanol extract of Jacaranda acutifolia Humb. and Bonpl. (JA) family Bignoniaceae was subjected to phytochemical investigation as well as antioxidant, hepatoprotective, cytotoxic and antihyperglycemic activities evaluation.Key findings: Eight compounds were identified: luteolin-7-O-β-D-glucuronide, luteolin-7-O-β-D-glucoside, aesculetin, luteolin, verbascoside, luteolin-7-O-β-D-glucuronide methyl ester, apigenin-7-O-β-D-glucuronide methyl ester and apigenin. JA revealed a potent antioxidant activity in vitro superior to vitamin E (DPPH assay; EC 50 of 0.43 mg/mL). A potential cytotoxic activity was produced against hepatocellular (HepG2) and cervical (HeLa) carcinoma cells with IC 50 of 6.05 and 16.7 µg, respectively. Treatment with JA extract inhibited the rise in alanine aminotransferase and aspartate aminotransferase by 33.6% and 36.8% respectively, reduced thiobarbituric acid by 35.7% and decreased the tamoxifen-induced elevation in tumor necrosis factor alpha (TNF-α) level by 42.86%. JA extract elicited a significant decrease in fasting blood glucose by -59.26%. Conclusions:Jacaranda acutifolia could be a natural source for antioxidant, hepatoprotective supplements and could provide a basis for a potential cytotoxic agent. The compounds isolated are responsible at least in part for the observed effects.

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“…Sieboldogenin, isolated from ethyl acetate fraction of Smilax china has potent anti-inflammatory activity 19 . In Traditional Chinese Medicine, it is used in the management of chronic pelvic inflammatory disease 18 , syphilis, acute bacterial dysentery and chronic nephritis 20 . The methanol extract of Smilax china exhibit antimicrobial activity 21 .…”

Section: Smilax Chinamentioning

confidence: 99%

Therapeutic Potency of a Siddha Formulation Kandhaga Rasayanam: A Review

Meena¹,

Rs²

2015

Int.J. Res. Ayurveda Pharm.

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Siddha system of medicine is one of the oldest systems of medicine practised among Tamil speaking community. The medicines in this system are prepared from raw materials like herbs, minerals/metals and animal products. Kandhaga Rasayanam is a herbo mineral formulation with 16 ingredients. It is used for treating skin diseases, arthritis, leucorrhoea, urinary diseases etc. This review is aimed to bring out scientific evidence for the therapeutic usage of Kandhaga Rasayanam and focussed on the pharmacological activity responsible for the curative nature of the drug. Most of its drugs have antimicrobial, anti-inflammatory activity hence justifying its usage in above mentioned diseases.

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A flavonoid glycoside isolated from Smilax china L. rhizome in vitro anticancer effects on human cancer cell lines

Cited by 132 publications

References 38 publications

NMR Metabolomics of Thrips (Frankliniella occidentalis) Resistance in Senecio Hybrids

NMR Metabolomics of Thrips (Frankliniella occidentalis) Resistance in Senecio Hybrids

Hepatoprotective, Antihyperglycemic and Cytotoxic Activities of Jacaranda acutifolia Leaf Extract

Therapeutic Potency of a Siddha Formulation Kandhaga Rasayanam: A Review

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