A finite element model of contusion spinal cord injury in rodents

Frantsuzov, Roman; Mondal, Subrata; Walsh, Ciara M.; Reynolds, James R.; Dooley, Dearbhaile; MacManus, David B.

doi:10.1016/j.jmbbm.2023.105856

Cited by 4 publications

(3 citation statements)

References 42 publications

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“…properties assumption is sufficient for our modeling purposes. [71][72][73][74][75][76][77][78] While it is true that incorporating material inhomogeneity could influence stress distribution and transmission at the bone trabeculae level, 79 for the purposes of this work, the focus was on macroscale stress changes pre and post VP using cements with varying Young's modulus values. Therefore, employing homogeneous properties was deemed sufficient.…”

Section: Limitationsmentioning

confidence: 99%

Finite element analysis of vertebroplasty in the osteoporotic T11‐L1 vertebral body: Effects of bone cement formulation

Mondal,

MacManus,

Banche‐Niclot

et al. 2024

J Biomed Mater Res

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Vertebral compression fractures are one of the most severe clinical consequences of osteoporosis and the most common fragility fracture afflicting 570 and 1070 out of 100,000 men and women worldwide, respectively. Vertebroplasty (VP), a minimally invasive surgical procedure that involves the percutaneous injection of bone cement, is one of the most efficacious methods to stabilise osteoporotic vertebral compression fractures. However, postoperative fracture has been observed in up to 30% of patients following VP. Therefore, this study aims to investigate the effect of different injectable bone cement formulations on the stress distribution within the vertebrae and intervertebral discs due to VP and consequently recommend the optimal cement formulation. To achieve this, a 3D finite element (FE) model of the T11‐L1 vertebral body was developed from computed tomography scan data of the spine. Osteoporotic bone was modeled by reducing the Young's modulus by 20% in the cortical bone and 74% in cancellous bone. The FE model was subjected to different physiological movements, such as extension, flexion, bending, and compression. The osteoporotic model caused a reduction in the average von Mises stress compared with the normal model in the T12 cancellous bone and an increment in the average von Mises stress value at the T12 cortical bone. The effects of VP using different formulations of a novel injectable bone cement were modeled by replacing a region of T12 cancellous bone with the materials. Due to the injection of the bone cement at the T12 vertebra, the average von Mises stresses on cancellous bone increased and slightly decreased on the cortical bone under all loading conditions. The novel class of bone cements investigated herein demonstrated an effective restoration of stress distribution to physiological levels within treated vertebrae, which could offer a potential superior alternative for VP surgery as their anti‐osteoclastogenic properties could further enhance the appeal of their fracture treatment and may contribute to improved patient recovery and long‐term well‐being.

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Section: Limitationsmentioning

confidence: 99%

Finite element analysis of vertebroplasty in the osteoporotic T11‐L1 vertebral body: Effects of bone cement formulation

Mondal,

MacManus,

Banche‐Niclot

et al. 2024

J Biomed Mater Res

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“…Finite element analysis can be utilized to compare the biomechanical properties of the cervical spine under physiological or pathological conditions by altering parameters and analyzing their effects. This enables an examination of pathological processes’ impact on the cervical spine’s mechanical characteristics ( Srinivasan et al, 2021 ; Frantsuzov et al, 2023 ; Hsieh et al, 2023 ). This method can evaluate the biomechanical effects of various spinal surgeries and assess the mechanical stability of different implants by calculating and analyzing parameters such as ROM, IDP, facet joint stress, and stress in the spinal cord, among other factors.…”

Section: Introductionmentioning

confidence: 99%

Biomechanical evaluation on a new type of vertebral titanium porous mini-plate and mechanical comparison between cervical open-door laminoplasty and laminectomy: a finite element analysis

Lin,

et al. 2024

Front. Bioeng. Biotechnol.

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Objective: Compare the spine’s stability after laminectomy (LN) and laminoplasty (LP) for two posterior surgeries. Simultaneously, design a new vertebral titanium porous mini plate (TPMP) to achieve firm fixation of the open-door vertebral LP fully. The objective is to enhance the fixation stability, effectively prevent the possibility of “re-closure,” and may facilitate bone healing.Methods: TPMP was designed by incorporating a fusion body and porous structures, and a three-dimensional finite element cervical model of C2-T1 was constructed and validated. Load LN and LP finite element models, respectively, and analyze and simulate the detailed processes of the two surgeries. It was simultaneously implanting the TPMP into LP to evaluate its biomechanical properties.Results: We find that the range of motion (ROM) of C4-C5 after LN surgery was greater than that of LP implanted with different plates alone. Furthermore, flexion-extension, lateral bending, and axial rotation reflect this change. More noteworthy is that LN has a much larger ROM on C2-C3 in axial rotation. The ROM of LP implanted with two different plates is similar. There is almost no difference in facet joint stress in lateral bending. The facet joint stress of LN is smaller on C2-C3 and C4-C5, and larger more prominent on C5-C6 in the flexion-extension. Regarding intervertebral disc pressure (IDP), there is little difference between different surgeries except for the LN on C2-C3 in axial rotation. The plate displacement specificity does not significantly differ from LP with vertebral titanium mini-plate (TMP) and LP with TPMP after surgery. The stress of LP with TPMP is larger in C4-C5, C5-C6. Moreover, LP with TMP shows greater stress in the C3-C4 during flexion-extension and lateral bending.Conclusion: LP may have better postoperative stability when posterior approach surgery is used to treat CSM; at the same time, the new type of vertebral titanium mini-plate can achieve almost the same effect as the traditional titanium mini-plate after surgery for LP. In addition, it has specific potential due to the porous structure promoting bone fusion.

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“…Finite element analysis allows for more accurate simulation of subtle morphological changes in the external and internal structures of tissues in response to mechanical forces and can be reused, greatly reducing research costs. The advent of 3D finite element models of cervical discs provides a new approach to the mechanistic study and therapeutic evaluation of spine-related diseases ( Cao et al, 2021 ; Frantsuzov et al, 2023 ; Komeili et al, 2021 ; Rycman et al, 2021 ; Vedantam et al, 2023 ; Xu et al, 2022 ; Yang et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Comparison of biomechanical parameters of two Chinese cervical spine rotation manipulations based on motion capture and finite element analysis

Lin

Weng

et al. 2023

Front. Bioeng. Biotechnol.

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Objective: The purpose of this study was to obtain the stress-strain of the cervical spine structure during the simulated manipulation of the oblique pulling manipulation and the cervical rotation-traction manipulation in order to compare the mechanical mechanism of the two manipulations.Methods: A motion capture system was used to record the key kinematic parameters of operating the two manipulations. At the same time, a three-dimensional finite element model of the C0-T1 full healthy cervical spine was established, and the key kinematic parameters were loaded onto the finite element model in steps to analyze and simulate the detailed process of the operation of the two manipulations.Results: A detailed finite element model of the whole cervical spine including spinal nerve roots was established, and the validity of this 3D finite element model was verified. During the stepwise simulation of the two cervical spine rotation manipulations to the right, the disc (including the annulus fibrosus and nucleus pulposus) and facet joints stresses and displacements were greater in the oblique pulling manipulation group than in the cervical rotation-traction manipulation group, while the spinal cord and nerve root stresses were greater in the cervical rotation-traction manipulation group than in the oblique pulling manipulation group. The spinal cord and nerve root stresses in the cervical rotation-traction manipulation group were mainly concentrated in the C4/5 and C5/6 segments.Conclusion: The oblique pulling manipulation may be more appropriate for the treatment of cervical spondylotic radiculopathy, while cervical rotation-traction manipulation is more appropriate for the treatment of cervical spondylosis of cervical type. Clinicians should select cervical rotation manipulations for different types of cervical spondylosis according to the patient’s symptoms and needs.

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A finite element model of contusion spinal cord injury in rodents

Cited by 4 publications

References 42 publications

Finite element analysis of vertebroplasty in the osteoporotic T11‐L1 vertebral body: Effects of bone cement formulation

Finite element analysis of vertebroplasty in the osteoporotic T11‐L1 vertebral body: Effects of bone cement formulation

Biomechanical evaluation on a new type of vertebral titanium porous mini-plate and mechanical comparison between cervical open-door laminoplasty and laminectomy: a finite element analysis

Comparison of biomechanical parameters of two Chinese cervical spine rotation manipulations based on motion capture and finite element analysis

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