A finite element analysis of the maxillary first molar <scp>PDL</scp> with maxillary protraction in a mixed dentition Class <scp>III</scp> malocclusion

Tanaka, Orlando Motohiro; Araújo, Eustáquio; Oliver, Dana; Behrents, Rolf G.

doi:10.1111/ocr.12102

Cited by 11 publications

(10 citation statements)

References 30 publications

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“…It is known that biomechanical models of the human TMJ are not perfect, rather they are based on a number of assumptions and simplifications. More specifically, biomechanical model could not mimic the influence of different cytokines such as IL-4, IL-6, and IL-12 [33][34][35]. In future studies, we aim to determine the nutrient environment in TMJ discs by using combined experimental and computational modelling approaches.…”

Section: Discussionmentioning

confidence: 99%

Finite elements analysis of the temporomandibular joint disc in patients with intra-articular disorders

et al. 2020

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Background: Intra-articular disorders (ID) or anterior and/or medial displacement of the temporomandibular joint disorder (TMJ) disc are the most common form of TMJ dysfunction (TMD). TMD causes changes in the friction coefficient during TMJ movement. Herein, we provided a three-dimensional (3D) finite-elements model (FEM) including the maxilla, disc, and mandible and evaluated the stress distribution with different friction coefficient. Methods: Fourteen volunteers without TMD and 20 patients with MRI-diagnosed TMD were selected. CT and MRI data were collected to build the 3D FEA model of the mandible and TMJ disc. Stress distribution with different friction coefficient was measured. Result: In the normal model, stress distribution on the TMJ disc was 2.07 ± 0.17, 1.49 ± 0.14, and 1.41 ± 0.14 MPa with 0.001, 0.3, and 0.4 friction coefficient, respectively. In the TMD model, stress distribution was 3.87 ± 0.15, 7.23 ± 0.22, and 7.77 ± 0.19 MPa respectively. Conclusion: When the friction coefficient of the side with anterior displacement increased, stress on the disc, condyle and mandible of the opposite side increased. Simultaneously, stress values of the disc, condyle and mandible were higher than those of the normal lateral joint.

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Section: Discussionmentioning

confidence: 99%

Finite elements analysis of the temporomandibular joint disc in patients with intra-articular disorders

et al. 2020

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“…PD-L1 and its signaling pathway appear to be a potential therapeutic target for cancer. Interestingly, a recent research demonstrated that PD-L1 expression had the capability to change over time with anti-PD-L1 antibody therapy [ 33 ]. Therefore, its expression status of a specific tumor tissue may not reflect the present immunologic phenotype of tumor.…”

Section: Chemotherapy Alters the Expression Of Pd-1/pd-l1mentioning

confidence: 99%

The effect of chemotherapy on programmed cell death 1/programmed cell death 1 ligand axis: some chemotherapeutical drugs may finally work through immune response

Luo

Fu²

2016

Oncotarget

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Most tumors are immunogenic which would trigger some immune response. Chemotherapy also has immune potentiating mechanisms of action. But it is unknown whether the immune response is associated with the efficacy of chemotherapy and the development of chemoresistance. Recently, there is a growing interest in immunotherapy, among which the co-inhibitory molecules, programmed cell death 1/programmed cell death 1 ligand (PD-1/PD-L1) leads to immune evasion. Since some reports showed that conventional chemotherapeutics can induce the expression of PD-L1, we try to summarize the effect of chemotherapy on PD-1/PD-L1 axis and some potential molecules relevant to PD-1/PD-L1 in chemoresistance in this review.

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“…In a 3D FEA model of a tooth‐periodontium system with complicated geometry, it is convenient to apply mechanical forces at any regions and in any directions . FEA has provided essential new knowledge for tooth restoration , prosthetic and orthodontic treatment , implant design , tooth fracture and periodontal trauma analysis, as well as the biomechanics of the mandibular system .…”

Section: Introductionmentioning

confidence: 99%

Finite element analysis on tooth and periodontal stress under simulated occlusal loads

Zhang

Cui

et al. 2017

J of Oral Rehabilitation

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The tooth stress elicited by occluding contact represents critical biomechanical information about dental health during chewing. Effects of occlusal contact on tooth stress remain obscure. In this study, a mandibular first molar finite element model was built from CT images. The effects of area size, location and direction of occlusal loading on both tooth and periodontal stresses were analysed. Results showed tooth and periodontal stress had drastically different patterns. Tooth stress value was much higher than periodontal stress value under the same task. Tooth stress concentration area and its value decreased from outside to inside. The Maximum Tooth Stress (MTS) always occurred at the loading site and a larger loading area elicited a smaller MTS value. The variation of MTS was larger when the fossa bottoms were inclined loaded than when the cusp tips were inclined loaded, larger when lingually loaded than when buccally loaded and larger when mesially loaded than when distally loaded. Distal loadings generally induced smaller Maximum Periodontal Stress (MPS) variations than the mesial loadings. These findings indicated exposure of the rational site(s) to occlusal contact should be helpful to achieve proper tooth and periodontal stress, thus to diminish loading associated structure problems.

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A finite element analysis of the maxillary first molar PDL with maxillary protraction in a mixed dentition Class III malocclusion

Abstract: The suggested orthodontic movement is in the mesial direction with a small amount of extrusion with 15° angulation and greater extrusion with 30° and 45°.

Cited by 11 publications

References 30 publications

Finite elements analysis of the temporomandibular joint disc in patients with intra-articular disorders

Finite elements analysis of the temporomandibular joint disc in patients with intra-articular disorders

The effect of chemotherapy on programmed cell death 1/programmed cell death 1 ligand axis: some chemotherapeutical drugs may finally work through immune response

Finite element analysis on tooth and periodontal stress under simulated occlusal loads

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