A Fine Structural Study of Liver (Littoral) Cells of Methylmercury Fed Japanese Quail (Coturnix coturnix japonica)

Gullvåg, B. M.; Aagdal, J.P.; Eskeland, B.

doi:10.1111/j.1600-0773.1978.tb02241.x

Acta Pharmacologica et Toxicologica

1978

DOI: 10.1111/j.1600-0773.1978.tb02241.x

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A Fine Structural Study of Liver (Littoral) Cells of Methylmercury Fed Japanese Quail (Coturnix coturnix japonica)

B. M. Gullvåg¹,

J.P. Aagdal²,

B. Eskeland

Abstract: Tissues of Japanese quails were subjected to electron microscopical study. The birds had received 0–8 ppm methylmercury added to their diets for 6 weeks. The ultrastructural changes in the littoral cells of the liver were swollen mitochondria, with dilatation of the endoplasmic reticulum, loss of ribosomes from the rough endoplasmic reticulum and an increase in the number of vesicles in the cytoplasm. The nuclear membrane in some littoral cells became dilated, and the nuclear chromatin was condensed. The physi… Show more

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Cited by 4 publications

References 6 publications

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Ultrastructural alterations produced in cockerels after mercuric chloride toxicity and subsequent interaction with an organophosphate insecticide

Chishti

Rotkiewicz

1992

Arch. Environ. Contam. Toxicol.

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Ultrastructural changes of liver and kidneys of cockerels exposed to mercuric chloride and subsequent interaction with methylobromofenvinphos (IPO 63 compound) were studied. Group A birds were treated for 4 weeks with 300 ppm mercuric chloride in drinking water; Group B birds were treated for 4 weeks with mercuric chloride followed by single oral dose of 240 mg/kg of IPO 63; Group C 240 mg/kg IPO 63 only; and Group D, unexposed controls. Hepatocytes of mercury-IPO 63 interaction group B showed large lysosomes containing myelin bodies, swollen mitochondria with cristeolysis, dilated endoplasmic reticulum and numerous vacuoles containing granular material. Mercury-intoxicated birds showed similar but less severe changes, whereas IPO 63-treated birds showed accumulation of glycogen granules, fat droplets, and few lysosomal bodies as well as other changes. Renal corpuscles of kidney from mercury-IPO 63 interaction birds revealed minor ultrastructural changes as vacuolation, swollen mitochondria of podocytes and slight thickening of the glomerular basement membrane. Proximal tubular cells showed extreme damage such as, microvillar loss, dilation of endoplasmic reticulum, accumulation of lysosomal bodies, glycogen granules, myelin figures, swollen mitochondria with granular material, numerous vacuoles containing degenerated membranous organelles and distorted, pyknotic nucleus with marked dilation of nuclear membrane. Mercury intoxicated birds showed similar but less pronounced changes in tubules. These observations suggest that the effect of mercuric chloride toxicity and then interaction with an organophosphorus insecticide causes extreme damage to hepatic and renal cells that appears to be additive.

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Ultrastructural alterations produced in cockerels after mercuric chloride toxicity and subsequent interaction with an organophosphate insecticide

Chishti

Rotkiewicz

1992

Arch. Environ. Contam. Toxicol.

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Quantitative Studies of Mercury and Cadium Deposition in Japanese Quail Through Multiple Generations

Eskeland¹,

Gullvåg²,

Nafstad³

1979

Acta Agriculturae Scandinavica

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Ultrastructural alterations of the liver of pekin ducks fed methyl mercury‐containing diets

Bhatnagar¹,

Vrablic²,

Yamashiro³

1982

Journal of Toxicology and Environmental Health

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This report describes the ultrastructural alterations of the liver of 24 male and 24 female Pekin ducks fed 0.0, 0.5, 5.0, and 15.0 ppm of methyl mercury chloride (MeHgCl), mixed in a mash diet, for 12 wk. Birds were weighed weekly and observed for neurologic symptoms daily. Samples of blood, liver, kidney, skeletal muscle and brain were analyzed for Hg residue by atomic absorption spectrophotometry. Livers were fixed in situ by perfusion with glutaraldehyde fixative and processed for electron microscopy. The percent decreases in mean body weights between wk 0 and wk 7 were statistically not significant except for males fed 5.0 ppm MeHgCl. Leg paralysis and convulsions in males treated with 15.0 ppm began at wk 5 and in females at wk 8, but were more severe in the latter. The dose-residue response for the three dose levels in all five tissues was linear, with liver and kidney containing the highest and the brain the least amount of Hg. Hepatocytes in 0.5- and 5.0-ppm MeHgCl treatment groups showed little morphologic changes, while liver cells in the 15.0-ppm group had several ultrastructural alterations, including remarkable increase in peribiliary lysosomal bodies. The mitochondria of some hepatocytes exhibited lysis of both inner and outer membranes. Changes also occurred in endothelial and Kupffer cells. These results indicate that dosing Pekin ducks with 15.0 ppm causes ultrastructural alterations indicative of toxic injury to the liver.

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A Fine Structural Study of Liver (Littoral) Cells of Methylmercury Fed Japanese Quail (Coturnix coturnix japonica)

Cited by 4 publications

References 6 publications

Ultrastructural alterations produced in cockerels after mercuric chloride toxicity and subsequent interaction with an organophosphate insecticide

Ultrastructural alterations produced in cockerels after mercuric chloride toxicity and subsequent interaction with an organophosphate insecticide

Quantitative Studies of Mercury and Cadium Deposition in Japanese Quail Through Multiple Generations

Ultrastructural alterations of the liver of pekin ducks fed methyl mercury‐containing diets

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