A Film‐Forming System Hybridized with a Nanostructured Chloroacetamide Derivative for Dermatophytosis Treatment

Abstract

Dermatophytosis is the fourth cause of infectious disease in the world, affecting about 40 % of the population. Thus, the prospection for new agents and the new formulations with antifungal potential is necessary. This study evaluated the antidermatophytic activity of a nanostructure (NS) containing a chloroacetamide derivative (4-BFCA-NS) as well as its doseresponse kinetics and skin adhesive property when associated to a film-forming system (4-BFCA-NS-FFS), forming a hybrid. The dose-response curves of 4-BFCA-NS and 4-BFCA-NS-FFS were evaluated by time-kill assay. A texture analyzer was used for evaluated the skin adhesive property of the formulations. NS presented a nanometric size, monomodal distribution, positive zeta potential, and slightly acidic pH. 4-BFCA-NS maintained the anti-dermatophytic action of 4-BFCA (MIC range 6.25-25 μg ml À 1 ). 4-BFCA-NS-FFS hybrid presented a fungicidal action and skin adhesive capacity, suggesting its applicability as a new topical formulation for the treatment of superficial and cutaneous dermatophytosis.