A field evaluation of mortality rate and growth performance in pigs vaccinated against porcine circovirus type 2

Horlen, Kyle; Dritz, S. S.; Nietfeld, Jerome C.; Henry, Steven C.; Hesse, Richard; Oberst, Richard D.; Hays, Michael P.; Anderson, Joseph; Rowland, Raymond R.R.

doi:10.2460/javma.232.6.906

Cited by 102 publications

(67 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies proved that all vaccines give very good results with respect to limiting losses due to PCVD (Kixmoller et al 2008, Fort et al 2009). In herds where losses associated to PCVD affect mainly growers and finishers vaccination of piglets should be applied (Cline et al 2008, Horlen et al 2008, Pejsak et al 2010. Additionally, ear necrosis reduction was reported in pigs after vaccination against PCV2 (Pejsak et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Influence of long-term vaccination of a breeding herd of pigs against PCV2 on reproductive parameters

Pejsak¹,

Kusior²,

Pomorska‐Mól³

et al. 2012

Polish Journal of Veterinary Sciences

View full text Add to dashboard Cite

The objective of the study was to evaluate an efficacy of sows vaccination protocols in the herd with serious problems affecting efficacy of reproduction. The study was performed in a large pig herd with about 1200 sows. Before vaccination against PCV2, farrowing rate in this farm was about 65%.Sows, boar and replacement gilts were immunized using Circovac vaccine (Merial, France) according to producer's recommendations. Parameters of production were analyzed since 2007 until 2010 in selected batches of sows inseminated at the same weeks of the year (17th, 18th, 19th and 20th) to eliminate seasonal variability. In total, 940 sows were subjected to the study. No significant changes in management during these years were introduced.The applied protocol of sow herd long-term vaccination proved to be very efficient. All measured production parameters: reproduction rate, number of piglets born alive, birth weight of piglets and number of piglets weaned per a litter improved after implementation of immunization program. Moreover, further improvement was observed with vaccination in the following reproduction cycles. The most spectacular effect of vaccination regarded average farrowing rate that increased from 64.76% in control group to 86.93% after basic vaccination. Two years after implementation of vaccination program this parameter reached 93.6%. Number of piglets weaned per sow per a litter improved from 10.31 to 11.74 after one year of vaccination and remained relatively stable through the following year. Simultaneously, the percentage of newborn piglets with birth weight < 1 kg decreased significantly (p < 0.05).To summarize, vaccination against PCV2 influenced positively the insemination rate, number of piglets born alive and weaned per litter as well as birth body weight and percentage of piglets weighing < 1 kg.

show abstract

Section: Introductionmentioning

confidence: 99%

Influence of long-term vaccination of a breeding herd of pigs against PCV2 on reproductive parameters

Pejsak¹,

Kusior²,

Pomorska‐Mól³

et al. 2012

Polish Journal of Veterinary Sciences

View full text Add to dashboard Cite

show abstract

“…orcine circovirus-associated disease (PCVAD) encompasses a variety of progressive disease syndromes that include a variety of clinical signs, such as respiratory distress, wasting, dermatitis, reduced growth performance, and reproductive failure (3,4,12). A new syndrome, acute pulmonary edema (APE), is characterized by the rapid onset of respiratory distress followed by death (5).…”

mentioning

confidence: 99%

“…CP expressed in baculovirus or Escherichia coli spontaneously forms a virus-like particle (VLP), demonstrating that CP alone is sufficient for capsid formation (15,19,45,46). Recombinant vaccines incorporating baculovirus-expressed CP (Bac-CP) are effective in reducing viremia, improving growth performance, and protecting against PCVAD (7,12,16,24). Another vaccine approach is the expression of CP using a PCV1 backbone (8).…”

mentioning

confidence: 99%

Recognition of the Different Structural Forms of the Capsid Protein Determines the Outcome following Infection with Porcine Circovirus Type 2

Trible

Suddith

Kerrigan

et al. 2012

J Virol

Self Cite

View full text Add to dashboard Cite

“…The results of these studies indicate that ORF2 plays a significant role in the recombination of PCV2a and PCV2b, which generates new viral strains with different ORF2 sizes. ORF2 encodes proteins that are associated with viral structure and virulence, such as Cap (Horlen et al, 2008). The Cap protein is considered one of the major antigenic determinants, and functions efficiently in viral attachment to host cell surface receptors (Misinzo et al, 2006;Finsterbusch and Mankertz, 2009).…”

Section: Discussionmentioning

confidence: 99%

Identification of natural recombinants derived from PCV2a and PCV2b

et al. 2015

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. Porcine circovirus type 2 (PCV2) is considered to be the main pathogen in PC-associated diseases, and significantly affects the global pig-producing industry. PCV2 continuously evolves by point mutations and genome recombinations. In the present study, we aimed to further identify recombinant PCV2 strains. We used polymerase chain reaction to detect PCV2 in the carcasses of pigs with suspected infections from different regions of Guangdong Province in China. DNA was extracted from samples with confirmed infection and fullgenome amplification, sequencing, phylogenetic tree construction, gene recombination detection, and sequence alignment were performed in gene recombination analysis. Our results show that recombination occurred between the strains SHC (DQ104421) and ZhuJi2003 (AY579893). The recombination resulted in three recombinants: GD003 (KM503044), GD005 (KM487708), and GD008 (KM487709). Further analyses revealed that these novel recombinants appeared to result from recombination between the PCV2a and PCV2b strains, with crossover regions located in ORF2. This study was a comprehensive analysis that used several different methods, which demonstrated that a cluster of PCV2 strains resulted from the same type of inter-genotypic 11781Recombinants from PCV2 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 11780-11790 (2015) recombination pattern, with a breakpoint in the structural protein coding region. The results of our study provide both information on the recombination mechanism and disease pathogenesis and useful data for the prevention of PCV2 in the swine industry.

show abstract

A field evaluation of mortality rate and growth performance in pigs vaccinated against porcine circovirus type 2

Abstract: Results suggested that vaccination against PCV2 was effective at reducing mortality rate and improving growth performance among pigs in a herd infected with PCV2.

Cited by 102 publications

References 22 publications

Influence of long-term vaccination of a breeding herd of pigs against PCV2 on reproductive parameters

Influence of long-term vaccination of a breeding herd of pigs against PCV2 on reproductive parameters

Recognition of the Different Structural Forms of the Capsid Protein Determines the Outcome following Infection with Porcine Circovirus Type 2

Identification of natural recombinants derived from PCV2a and PCV2b

Contact Info

Product

Resources

About