A fiber-shaped neural probe with alterable elastic moduli for direct implantation and stable electronic–brain interfaces

Tang, Chengqiang; Xie, S.; Wang, Mengying; Feng, Jianyou; Han, Zhengqi; Wu, Xiaoying; Wang, Liyuan; Chen, Chuanrui; Wang, Jiajia; Jiang, Liping; Chen, Peining; Sun, Xuemei; Peng, Huisheng

doi:10.1039/d0tb00508h

Cited by 41 publications

(45 citation statements)

References 38 publications

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“…Astrocytes, immune-reactive cells labeled by glial fibrillary acidic protein (GFAP), were shown to be populated more densely near the silica fiber implant than the OWHF implant (Fig. 5 g and i), indicating that the silica fiber implant triggered a more severe immune response than the OWHF implant [ 6 , 45 ]. In the OWHF - implanted cortical tissue, IgG, a common serum antibody in blood circulation [ 46 ], was restricted to the vasculature and removed upon perfusion (Fig.…”

Section: Resultsmentioning

confidence: 99%

Integrated dynamic wet spinning of core-sheath hydrogel fibers for optical-to-brain/tissue communications

Chen

Wang

Tan

et al. 2020

National Science Review

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Hydrogel optical light-guides have received substantial interest for applications such as deep-tissue biosensors, optogenetic stimulation and photomedicine due to their biocompatibility, (micro)structure control and tissue-like Young's modulus. However, despite recent developments, the large-scale fabrication with a continuous synthetic methodology, which could produce core-sheath hydrogel fibers with the desired optical and mechanical properties suitable for deep-tissue applications has yet to be achieved. In this study, we report a versatile concept of integrated light-triggered dynamic wet spinning (ILDWS), which capable of continuously producing core-sheath hydrogel optical fibers with tunable fiber diameters, mechanical and optical-propagation properties. Furthermore, this concept also exhibited versatility for various kinds of core-sheath functional fibers. The wet spinning synthetic procedure and fabrication process were optimized with the rational design of the core/sheath material interface compatibility [core = poly(ethylene glycol diacrylate-co-acrylamide); sheath = Ca-alginate], optical transparency, refractive index and spinning solution viscosity. The resulting hydrogel optical fibers exhibited desirable low optical attenuation (0.18 ± 0.01 dB cm−1 with 650 nm laser light), excellent biocompatibility and tissue-like Young's modulus (< 2.60 MPa). The optical-waveguide hydrogel fibers (OWHFs) were successfully employed for deep-tissue cancer therapy and brain optogenetic stimulation, confirming that they could serve as an efficient versatile tool for diverse deep-tissue therapy and brain optogenetic applications.

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Section: Resultsmentioning

confidence: 99%

Integrated dynamic wet spinning of core-sheath hydrogel fibers for optical-to-brain/tissue communications

Chen

Wang

Tan

et al. 2020

National Science Review

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“…The authors then suggested the use of CFs as an alternative shuttle device as a means to reduce the insertion footprint. In a more recent study reported by Tang et al (2020), the authors functionalized CNT fibers with a layer of calcium ion crosslinked sodium alginate. The functionalized fiber electrodes are rigid before implantation but become softer after insertion.…”

Section: Carbon Nanotube (Cnt)-based Fibersmentioning

confidence: 99%

Advances in Carbon-Based Microfiber Electrodes for Neural Interfacing

et al. 2021

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Neural interfacing devices using penetrating microelectrode arrays have emerged as an important tool in both neuroscience research and medical applications. These implantable microelectrode arrays enable communication between man-made devices and the nervous system by detecting and/or evoking neuronal activities. Recent years have seen rapid development of electrodes fabricated using flexible, ultrathin carbon-based microfibers. Compared to electrodes fabricated using rigid materials and larger cross-sections, these microfiber electrodes have been shown to reduce foreign body responses after implantation, with improved signal-to-noise ratio for neural recording and enhanced resolution for neural stimulation. Here, we review recent progress of carbon-based microfiber electrodes in terms of material composition and fabrication technology. The remaining challenges and future directions for development of these arrays will also be discussed. Overall, these microfiber electrodes are expected to improve the longevity and reliability of neural interfacing devices.

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“…[ 117 ] To further simplify the implantation process, a fiber electrode with alterable elastic moduli was developed (Figure 8A). [ 27 ] The electrode based on CNT fiber exhibited as rigid as metal wires to ensure facile and direct implantation and turned as soft as brain tissue after implantation to ensure dynamic and stable interfaces (Figure 8B). It delivered a stable neuron recording for 4 weeks in vivo.…”

Section: Electrochemical Sensorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Flexible sensors based on assembled carbon nanotubes

Yang

Liao

et al. 2021

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Flexible sensors have attracted significant attention as they could be directly attached to/implanted into the body or incorporated into textiles to monitor human activities and give feedbacks for healthcare. A typical fabrication method is the direct use of intrinsically flexible active materials such as carbon nanotubes (CNTs). CNTs are generally assembled into aligned structures to extend their remarkable chemical, mechanical, and electrical properties to macroscopic scale to afford high sensing performances. In this review, we present the recent advance of CNT assemblies as electrodes or functional materials for flexible sensors. The realizations of aligned CNTs are firstly investigated. A variety of flexible sensors based on the aligned CNTs are then carefully explored, with an emphasis on understanding the working mechanism for their high sensing properties. The main attention is later paid to comparing two main categories of flexible sensors with fiber and film shapes. The remaining challenges are finally highlighted to offer some insights for future study.

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A fiber-shaped neural probe with alterable elastic moduli for direct implantation and stable electronic–brain interfaces

Abstract: A fiber-shaped neural probe with alterable elastic moduli allows direct implantation and enables adaptive electronic–tissue interfaces post implantation.

Cited by 41 publications

References 38 publications

Integrated dynamic wet spinning of core-sheath hydrogel fibers for optical-to-brain/tissue communications

Integrated dynamic wet spinning of core-sheath hydrogel fibers for optical-to-brain/tissue communications

Advances in Carbon-Based Microfiber Electrodes for Neural Interfacing

Flexible sensors based on assembled carbon nanotubes

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