A fertilin-derived peptide improves in vitro maturation and ploidy of human oocytes

Cyclic fertilin-derived peptide stimulates in vitro human embryo development

“…Using a greater concentration of the molecule did not provide any best results in the Gardner classification or hatching rate. Furthermore, in another study dealing with human germinal vesicle stage oocyte in vitro maturation (17), the concentration of 1 mM gave also better results than 100 mM. As far as pharmacologic data are concerned, it is interesting to note that the molecule has no effect at the too low concentration of 0.1 mM on the developing embryos.…”

“…According to these properties, we ran a maturation study using immature human oocytes that had remained at the germinal vesicle stage and demonstrated that cFEE improves the percentage of euploid metaphase II oocytes and reduces the percentage of ''chaotic'' oocytes containing 2 or more chromosome abnormalities (17). The molecule also binds to the human embryo blastomeres, which means that a receptor may be present on its membrane.…”