A Fermentation State Marker Rule Design Task in Metabolic Engineering
Egils Stalidzans,
Reinis Muiznieks,
Konstantins Dubencovs
et al.
Abstract:There are several ways in which mathematical modeling is used in fermentation control, but mechanistic mathematical genome-scale models of metabolism within the cell have not been applied or implemented so far. As part of the metabolic engineering task setting, we propose that metabolite fluxes and/or biomass growth rate be used to search for a fermentation steady state marker rule. During fermentation, the bioreactor control system can automatically detect the desired steady state using a logical marker rule.… Show more
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