A fekélybetegség és a stressz

Herszényi, László; Juhász, Márk; Mihály, Emese; Tulassay, Zsolt

doi:10.1556/650.2015.30249

Cited by 12 publications

(7 citation statements)

References 21 publications

(22 reference statements)

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“…As we know, peptic ulcer patients with HP infection often show a huge damage of gastric mucosa. 13 Many histological and histochemical changes takeg place in the gastric mucosa, such as inflammatory cell infiltration, structure disorder, loose arrangement, and mucosal thickness increase. Thus, we first have to separate the gastric mucosal tissue of different treatment groups for HE analysis.…”

Section: Cyyy-induced Gastric Mucosa Histological Change In Peptic Ul...mentioning

confidence: 99%

The influence of the Chuyou Yuyang granule on the Toll‐like receptor/nuclear factor‐κB signal pathway in Helicobacter pylori‐positive peptic ulcer patients

Yang

Shen

et al. 2019

J of Cellular Biochemistry

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Background: The cure rate of Helicobacter pylori (HP)-positive peptic ulcer has appeared to downward trend, and the resistance of the ulcer relapse has become a hot issue. Methods: Hematoxylin and eosin staining was used to detect the repair of the damaged tissues in patients after treatment with the Chuyou Yuyang granule (CYYY). Elisa was used to analyze the expression of cytokine interleukin 18 (IL-18) and tumor necrosis factor α (TNF-α) in the patients' serum. Western blot analysis was used to explore the mechanism of the CYYY. Reverse-transcription polymerase chain reaction (RT-PCR) was used to detect the expression of microRNA-155a (miR-155a) and miR-146a in the blood of the patients and to confirm whether CYYY could cure peptic ulcer through regulation of miR-155a and miR-146a. Results:The damaged gastric mucosal tissues of ulcer patients were significantly repaired by treating with CYYY. The pro-inflammatory cytokine IL18 and TNF-α were notably repressed after treating with CYYY. In addition, CYYY played a key role in regulation of the Toll-like receptor (TLR4)/nuclear factor-κB (NF-κB) signal pathway and the expression of miR-155a and miR-146a.Conclusion: CYYY was a highly effective therapeutic method for peptic ulcer patients by inhibiting the activation of the TLR4/NF-κB signal pathway and suppressing the expression of miR-155a and miR-146a. K E Y W O R D SChuyou Yuyang granule, Toll-like receptor/nuclear factor-κB signal, ulcer patients J Cell Biochem. 2019;120:13745-13750.wileyonlinelibrary.com/journal/jcb

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Section: Cyyy-induced Gastric Mucosa Histological Change In Peptic Ul...mentioning

confidence: 99%

The influence of the Chuyou Yuyang granule on the Toll‐like receptor/nuclear factor‐κB signal pathway in Helicobacter pylori‐positive peptic ulcer patients

Yang

Shen

et al. 2019

J of Cellular Biochemistry

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“…A study also shows that stressors can disrupt the function of GI microbiota by inducing a neural response, which increases the risk of mucosal infection and inflammation. Stress on the GI mucosal immune system can lead to the translocation of pathogenic microbes from the GI tract to the interior of the body, with the resultant infection and the associated inflammatory response [40]. Se-vere and sustained anxiety can induce peptic ulceration.…”

Section: Anxiety and Spleen Functionmentioning

confidence: 99%

“…A causal relationship between anxiety and peptic ulceration is supported by clinical and experimental observations. It has been shown, for example, that stress, which is correlated to anxiety, can cause peptic ulcer in absence of Helicobacter pylori [40]. An increase in the number of patients with peptic ulcers that are not caused by bacteria or non-steroidal anti-inflammatory drugs was observed after the traumatic earthquake in East Japan on 11 March, 2011, suggesting that psychological stress arising from this natural disaster can be a significant factor in causing peptic ulcers [41].…”

Section: Anxiety and Spleen Functionmentioning

confidence: 99%

Spleen Function and Anxiety in Chinese Medicine: A Western Medicine Perspective

Chung¹,

Chen²,

Ko³

2016

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This article aims to illustrate the function of the Spleen in Traditional Chinese Medicine (TCM) in the context of modern medicine. TCM has been practiced since ancient times in China for the prevention and/or treatment of diseases. Yet, the complete understanding of its theoretical basis in relation to clinical practice from the modern medicine perspective is still lacking. According to TCM theory, the Spleen, as one of the five Zang (i.e., visceral organs), plays an important role in various physiological functions, including digestion and absorption of nutrients, regulation of water retention and excretion, facilitation of blood perfusion to skeletal muscle and on the optimal functioning of the immune system. Clinical applications of herbal formulations for the treatment of Spleen dysfunction (i.e., Spleen deficiency-a decline in Spleen function) and their pharmacological activities are described. The view point of TCM on how emotions (or Qing Zhi) can influence the body function is introduced. The relationship between anxiety and Spleen function has been analyzed by reviewing relevant research studies in modern medicine. These findings suggest that the cause/consequence relationship between anxiety and Spleen function may be bi-directional.

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“…), так и внутренние факторы риска (патология нервной и гуморальной регуляции, эндокринной системы и др.). Вклад наследственной предрасположенности (повышение чувствительности организма к действию других факторов риска) к развитию заболевания может достигать 50% H. рylori также может играть роль в патогенезе язвенной болезни, однако не является ее причиной, т. к. инфицированность H. рylori среди населения составляет более 60%, а язвенной болезнью страдают лишь 10-15% [4,[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25].…”

Section: Introductionunclassified

Contribution of intergenic interactions of polymorphic variants of candidate genes to the development of gastric ulcer

Рашина

Чурносов

2023

jour

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Introduction: Gastric ulcer is a chronic disease with a recurrent course. The morphological substrate during periods of exacerbation are ulcers of the gastric mucosa. Peptic ulcer disease has a high prevalence among the adult population and is often characterized by a complicated course. Hereditary predisposition, along with other external and internal risk factors, plays a role in the etiopathogenesis of the disease. The aim of the study: To evaluate the effect of polymorphic variants of cell adhesion molecule genes on the development of Helicobacter pylori-negative gastric ulcer (GU). Materials and methods: 119 patients with Helicobacter pylori-negative GU and 347 individuals of the control group were examined. The regulatory potential of 7 polymorphic loci of genes of cell adhesion molecules pathogenetically significant for the development of gastric ulcer (rs6136 of the SELP gene, rs8176720, rs2519093, rs507666 of the ABO gene, rs651007, rs579459, rs649129 of the ABO/RF00019 gene) was evaluated using the HaploReg v4.1, PolyPhen-2, GTEx Portal Internet resources. DNA samples isolated from peripheral blood were genotyped by PCR. The analysis of associations was carried out by the method of logistic regression in the framework of allelic, additive, dominant and recessive genetic models. Results: The T allele of the RF00019/ABO gene (rs651007) is a protective factor in the development of H. pylori-negative GU (OR=0.14). This polymorphism is located in the region of histones marking promoters, regions of hypersensitivity to DNAse and the HNF4 regulatory motif, is associated with the expression of the ABO and SURF1 genes and alternative splicing of the ABO and LCN1P1 genes in various organs (tissues), including in the organs of the digestive and nervous systems.

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A fekélybetegség és a stressz

Cited by 12 publications

References 21 publications

The influence of the Chuyou Yuyang granule on the Toll‐like receptor/nuclear factor‐κB signal pathway in Helicobacter pylori‐positive peptic ulcer patients

The influence of the Chuyou Yuyang granule on the Toll‐like receptor/nuclear factor‐κB signal pathway in Helicobacter pylori‐positive peptic ulcer patients

Spleen Function and Anxiety in Chinese Medicine: A Western Medicine Perspective

Contribution of intergenic interactions of polymorphic variants of candidate genes to the development of gastric ulcer

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