A feedback loop that drives cell death and proliferation and its defect in intestinal stem cells
Shivakshi Sulekh,
Yuko Ikegawa,
Saki Naito
et al.
Abstract:Cell death and proliferation are at a glance dichotomic events, but occasionally coupled. Caspases, traditionally known to execute apoptosis, play non-apoptotic roles, but their exact mechanism remains elusive. Here, usingDrosophilaintestinal stem cells (ISCs), we discovered that activation of caspases induces massive cell proliferation rather than cell death. We elucidate that a positive feedback circuit exists between caspases and JNK, which can simultaneously drive cell proliferation and cell death. In ISCs… Show more
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