A feces collection paper does not enhance participation in a fecal immunochemical test-based colorectal cancer screening program

Abstract

Discomfort with the collection of a stool sample is a frequently cited barrier for participation in fecal test-based colorectal cancer screening. The objective was to evaluate whether a feces collection paper enhances participation in a fecal immunochemical test (FIT)-based colorectal cancer screening program. Randomized clinical trial. Second round of a biannual Dutch FIT-based colorectal cancer screening program pilot. A random sample of 10 265 individuals from the general population, men and women aged 50-75 years at an average risk for colorectal cancer, was eligible for participation. Invitees were randomized to an FIT-only group (n=5136) or an FIT in combination with a feces collection paper group (n=5129). The main outcome measure was participation in screening. Overall, 5367 tests of 10 265 were returned (52%). In the FIT-only group, 2694 tests were returned [52%; 95% confidence interval (CI): 51-54%] versus 2673 tests in the collection paper group (52%; 95% CI: 51-54%). This difference in the participation rate was not significant (relative risk: 0.99; 95% CI: 0.97-1.04). A feces collection paper does not increase participation rates in FIT-based colorectal cancer screening. Future studies should explore other ways of facilitating participation in colorectal cancer screening programs.

Effectiveness of reminder strategies on cancer screening adherence: a randomised controlled trial

“…The use of personal invitations and reminders sent by primary care practitioners has been highlighted as a priority for interventions that aimed to enhance CRC screening adherence. Previous studies examining the effectiveness of various strategies have, in general, provided encouraging results, both in organised [7][8][9][10][11][12][13][14][15][16][17][18][19][20] and opportunistic settings targeted towards the organisation of practices and/or patients for CRC screening. 3 One of the principles of improving adherence rates includes influencing behavioural change, using an interplay of predisposing, enabling, and reinforcing factors, based on the PRECEDE-PROCEED model.…”

Colorectal cancer, screening: achievements и opportunities

“…В то же время в исследовании M. J. Denters и соавт. (n = 10 265) доля скринингового участия населения с применением FIT составила всего 52 % (95 % ДИ 51-54) [43]. И все же большинство исследователей считают, что FIT может обеспечить более высокую эффективность в сравнении с gFOBT за счет именно более высоких показателей участия, поэтому FIT все чаще используется вместо gFOBT в странах, внедряющих программы скрининга [44].…”

Inflammatory bowel disease detection and monitoring by measuring biomarkers in non‐invasively collected colorectal mucus

“…Among fecal biomarkers, stool calprotectin (SC) quantification is the best studied and most widely used test for IBD . Unfortunately, the necessity of collecting stool often makes stool testing unpopular with patients . Moreover, it is well known that diagnostically informative cells and biomolecules detectable in stool originate from the mucus of the protective barrier overlaying colonic mucosa .…”

“…[9][10][11][12][13][14] Unfortunately, the necessity of collecting stool often makes stool testing unpopular with patients. [15][16][17] Moreover, it is well known that diagnostically informative cells and biomolecules detectable in stool originate from the mucus of the protective barrier overlaying colonic mucosa. [18][19][20] Excreted fragments of this mucus are not uniformly distributed throughout stool, and sampling bias may be significant, especially when samples are prepared by patients.…”