2014
DOI: 10.1186/1471-2105-15-274
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A feature selection method for classification within functional genomics experiments based on the proportional overlapping score

Abstract: BackgroundMicroarray technology, as well as other functional genomics experiments, allow simultaneous measurements of thousands of genes within each sample. Both the prediction accuracy and interpretability of a classifier could be enhanced by performing the classification based only on selected discriminative genes. We propose a statistical method for selecting genes based on overlapping analysis of expression data across classes. This method results in a novel measure, called proportional overlapping score (… Show more

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Cited by 43 publications
(64 citation statements)
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References 38 publications
(71 reference statements)
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“…The method is implemented in an R package OTE. The proposed method could better be used, in conjunction with some feature selection method, (Mahmoud et al (2014a(Mahmoud et al ( , 2014b, for example) in high dimensional settings.…”
Section: Resultsmentioning
confidence: 99%
“…The method is implemented in an R package OTE. The proposed method could better be used, in conjunction with some feature selection method, (Mahmoud et al (2014a(Mahmoud et al ( , 2014b, for example) in high dimensional settings.…”
Section: Resultsmentioning
confidence: 99%
“…Table 2 shows the 15 selected features from the entire features space extracted from the trace file that are generated in ns-2. POS is considered the most suitable and efficient scheme with a dataset that has common classification problems such as outliers and high-dimensional binary [36,37]. It was employed to calculate the overlapping rate in the features extracted.…”
Section: Feature Sets and Extractionmentioning
confidence: 99%
“…It was employed to calculate the overlapping rate in the features extracted. The R code the POS method using the following pseudocode [36]:…”
Section: Feature Sets and Extractionmentioning
confidence: 99%
“…These features dramatically decrease the prediction performance of the algorithms (Nettleton et al (2010)). Feature selection methods that investigate the most discriminative features from the original features are usually recommended to mitigate the effect of such non-informative features (Mahmoud et al 2014a(Mahmoud et al , 2014b. However, different feature selection methods result in different feature subsets for the same data set thus varying feature relevancy.…”
Section: Introductionmentioning
confidence: 99%