A Feast of Malaria Parasite Genomes

Carlton, Jane M.; Sullivan, Steven A.

doi:10.1016/j.chom.2017.02.019

Cited by 5 publications

(6 citation statements)

References 9 publications

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“…Non-human primates (NHPs) share malaria parasites with humans and host-switching is an ongoing evolutionary process. Plasmodium knowlesi contrasts with many other parasite species because it has the capability of infecting both immature and mature stage erythrocytes in humans, and infects both monkey and human hosts [14]. This unique capacity relates to differences in the multigene families and the proteins they encode for in the human and NHP Plasmodium species/strains.…”

Section: Introductionmentioning

confidence: 99%

“…This unique capacity relates to differences in the multigene families and the proteins they encode for in the human and NHP Plasmodium species/strains. The genetic differences appear to be critical in determining current and potential hosts and host-switching capabilities [14]. The evolution of these differences has arisen over millennia, in parallel with the evolution of mammals.…”

Section: Introductionmentioning

confidence: 99%

“…There are now six species of human malaria parasites; Plasmodium falciparum , Plasmodium vivax , Plasmodium ovale ( Plasmodium ovale wallikeri and P. o. curtisi ), Plasmodium malariae and Plasmodium knowlesi [14, 18]. At least 30 Plasmodium species cause infection in the NHPs [19, 20] infecting 53 host species over 25 genera [21].…”

Section: Introductionmentioning

confidence: 99%

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Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework

Davidson

Chua

Cook

et al. 2019

Malar J

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Plasmodium knowlesi is a zoonotic malaria parasite normally residing in long-tailed and pig-tailed macaques ( Macaca fascicularis and Macaca nemestrina, respectively) found throughout Southeast Asia. Recently, knowlesi malaria has become the predominant malaria affecting humans in Malaysian Borneo, being responsible for approximately 70% of reported cases. Largely as a result of anthropogenic land use changes in Borneo, vectors which transmit the parasite, along with macaque hosts, are both now frequently found in disturbed forest habitats, or at the forest fringes, thus having more frequent contact with humans. Having access to human hosts provides the parasite with the opportunity to further its adaption to the human immune system. The ecological drivers of the transmission and spread of P. knowlesi are operating over many different spatial (and, therefore, temporal) scales, from the molecular to the continental. Strategies to prevent and manage zoonoses, such as P. knowlesi malaria require interdisciplinary research exploring the impact of land use change and biodiversity loss on the evolving relationship between parasite, reservoir hosts, vectors, and humans over multiple spatial scales.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework

Davidson

Chua

Cook

et al. 2019

Malar J

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“…Within Africa, multiple studies using different techniques have shown admixture to be a common theme in the recent history of the continent Pagani et al (2012); Schlebusch et al (2012); Pickrell et al (2012, 2014); Pickrell and Reich (2014); Busby et al (2016); Patin et al (2017); Carlton and Sullivan (2017); Amer (2017); Skoglund et al (2017). As a result, the genomes of individuals from these populations contain segments which derive from multiple ancestries.…”

Section: Introductionmentioning

confidence: 99%

Inferring adaptive gene-flow in recent African history

Busby

Christ

Leffler

et al. 2017

Preprint

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Gene-flow from an ancestrally differentiated group has been shown to be a powerful source of selectively advantageous variants. To understand whether recent gene-flow may have contributed to adaptation among humans in sub-Saharan Africa, we applied a novel method to identify deviations in ancestry inferred from genome-wide data in 48 populations. Among the signals of ancestry deviation that we find in the Fula, an historically pastoralist ethnic group from the Gambia, are the region that encodes the lactose persistence phenotype, LCT/MCM6, which has the highest proportion of Eurasian ancestry in the genome. The region with the lowest proportion of non-African ancestry is across DARC, which encodes the Duffy null phenotype and is protective for Plasmodium vivax malaria. In the Jola from the Gambia and a Khoesan speaking group from Namibia we find multiple regions with inferred ancestry deviation including the Major Histocompatibility Complex. Our analysis shows the potential for adaptive gene-flow in recent human history.

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“…Проте чи може існувати такий геном у природі, коли збудник на такому великому ареалі має постійно пристосовуватись до різних генотипів/ фенотипів людей, різних генотипів/фенотипів переносників, різних кліматичних умов? [13].…”

Section: біологічна безпекаunclassified

Modern biological research of Plasmodium vivax malaria pathogen

Pavlichenko¹

2019

Ecological Sciences

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У статті наведено дані глобальної захворюваності на vivax-малярію, її поширеність та можливу реінтродукцію в країнах, де вона була ліквідована. Аналіз сучасних генетичних, епідеміологічних та екологічних досліджень Plasmodium vivax пояснює його унікальні біологічні характеристики та взаємодію з хазяїном і вектором, що можна використати для розробки антималярійних вакцин. Ключові слова: Plasmodium vivax, vivax-малярія, геном, гіпнозоїт, рецидив, реінтродукція. Современные биологические исследования возбудителя трехдневной малярии. Павличенко В.И. В статье приведены данные глобальной заболеваемости на vivax-малярию, ее распространение и возможную реинтродукцию в странах, где она была ликвидирована. Анализ современных генетических, эпидемиологических и экологических исследований Plasmodium vivax объясняет его уникальные биологические характеристики и взаимоотношения с хозяином и вектором, что можно использовать при разработке антималярийных вакцин. Ключевые слова: Plasmodium vivax, vivax-малярия, геном, гипнозоит, рецидив, реинтродукция. Modern biological research of Plasmodium vivax malaria pathogen. Pavlichenko V. The article presents the global vivaxmalaria incidence, its prevalence and possible reintroduction in countries where it was eliminated. The analysis of modern genetic, epidemiological and ecological studies of Plasmodium vivax explains its unique biological characteristics and interaction with the host and vector that can be used to develop anti-malaria vaccines.

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A Feast of Malaria Parasite Genomes

Cited by 5 publications

References 9 publications

Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework

Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework

Inferring adaptive gene-flow in recent African history

Modern biological research of Plasmodium vivax malaria pathogen

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