A Feasible Synthesis of (−)‐Menthol‐Amino Acid Conjugates as Potential TRPM8 Agonists
P. Deepalekshmi,
B. Mahadevaprasad,
S. N. Apoorva
et al.
Abstract:A simple and feasible protocol for synthesizing the menthol‐amino acid conjugates by reacting t‐Boc‐amino acids with (1R,2S,5R)‐(−)‐menthol is reported. The synthesis involved the formation of an ester bond between the protected amino acid and (−)‐menthol using DCC, and DMAP as reagents. The t‐Boc‐menthol conjugates are deprotected using TFA in DCM to afford the menthol‐amino acid conjugates in excellent yield (>85 %). (−)‐Menthol possesses therapeutic properties, while amino acids are known for their diver… Show more
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