“…On the other hand, both PrP C and α-synuclein have ferrireductase activity that regulates the Fe 2+ /Fe 3+ ratio in synapses, thereby, controlling the neurotransmitter synthesis [15] , [145] , [146] . However, when homeostasis of metals is interrupted, degradation of neuronal synapses occurs, contributing to the pathogenesis of neurological disorders [15] , [19] , [149] , [150] . A mechanism of metal imbalance in the synapse, contributing to neurological disorders has also been suggested ( Fig.…”