A feasible method for isolation of pongamol from karanja (Pongamia pinnata) seed and its anti-inflammatory activity

Rekha, M.; Bettadaiah, B. K.; Kanya, T.C. Sindhu; Govindaraju, K.

doi:10.1016/j.indcrop.2020.112720

Cited by 12 publications

(7 citation statements)

References 50 publications

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“…Our study further confirms this by comparing different drying methods' spectral reflectance analysis, which can help determine the optimal drying method for producing high-quality rice products. In addition, similar to previous research, our results also show that the texture and color of grain samples processed by different drying methods can differ significantly, which may be attributed to the varying degree of extrusion and uneven heating during the drying process ( Acuff and Aldrich, 2022 ; Malahayati and Masui, 2022 ; Rekha et al, 2020 ). In addition, our results also demonstrate that spectral reflectance can be used to evaluate the quality of grain products, and it can be successfully applied to the comparative analysis of different drying methods, which provides a more effective method for assessing grain quality and assisting producers to strengthen management.…”

Section: Results Analysissupporting

confidence: 89%

Enhancing grain drying methods with hyperspectral imaging technology: A visualanalysis

Yang,

Cao,

et al. 2024

Current Research in Food Science

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Section: Results Analysissupporting

confidence: 89%

Enhancing grain drying methods with hyperspectral imaging technology: A visualanalysis

Yang,

Cao,

et al. 2024

Current Research in Food Science

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“…The release performance is much more superior to the earlier findings of 4-12 days (Pavela and Herda, 2007). Sansukcharearnpon et al (2010) found that most patented and commercialized agrochemical formulations are based on micro and nano-encapsulation for improved persistence and reduced active ingredient losses.…”

Section: Encapsulation Efficiency (Ee) and Release Of Pomentioning

confidence: 99%

“…Pongamia pinnata (L.) plant (Family: Fabaceae) is a medium-sized glabrous semi-evergreen tree growing in tropical regions ( Malaikozhundan and Vinodhini, 2018 ). It is being cultivated in a large number of gardens and along the countless roads in India, attributed to having several medicinal and therapeutic properties ( Rekha et al., 2020 ). The seeds of the plant containing karanjin , a furano-flavonoid compound have been reported to possess insecticidal activity ( Raghav et al., 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Encapsulation, release and insecticidal activity of Pongamia pinnata (L.) seed oil

Purkait

Mukherjee

Hazra

et al. 2021

Heliyon

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Pongamia pinnata (L.) seed oil is effective for its insecticidal and larvicidal activities. However, its low aqueous solubility, high photosensitivity, and high volatility restrict its application for the control of agricultural pests. Encapsulation can be an effective technique to overcome such hindrances. Therefore, P. pinnata oil (PO) was extracted from its seeds and analyzed for karanjin content (3.18%) by GC-MS/MS as the marker compound. Micro-encapsulation (MC) of PO was prepared by interfacial polymerization between isocyanates and polyamine and tested for insecticidal and larvicidal activities. Bioassay of the developed formulations was tested in-vitro against 2 nd instar larvae of Bombyx mori (Bivoltine hybrid) and in-vivo insecticidal bio-efficacy was tested against aubergine aphid ( Aphis gossypii G.) and whitefly ( Bemisia tabaci G.). Various properties of micro-capsules viz., stability, size, oil content and release kinetics were examined. Average diameter of capsules (1 μm) with Zeta potential (-16 mV) was indicated by the Dynamic Light Scattering (DLS) instrument. Existence of PO in the microcapsules was confirmed by an optical microscopic study. Spectroscopic analysis revealed 87.4% of PO was encapsulated in polyurea shell. The shelf-life ( T 10 ), half-life ( T 50 ), and expiry-life ( T 90 ) of polyurea coated capsules were 11.4, 75.3 and 250.0 h, respectively. Polyurea coated PO capsule formulation showed evidence of in-vitro toxicity against 2 nd instar larvae of B. mori ( LC 50 = 1.1%; LC 90 = 5.9%). The PO formulation also exhibited 67.0–71.8% and 62.4–74.8% control of aphid and whitefly population in aubergine at 4.0% dose following 7–14 days after application. The study unveiled its significance in developing controlled release herbal formulations of P. pinnata as an alternative to harmful conventional synthetic insecticides for crop protection.

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“…Previous studies have shown that it has a wide range of biological activities, including antioxidant, antidiabetic, antiulcer, and anticancer effects . Besides, pongamol has been shown to exert anti-inflammatory activity in a rat model . However, there have been no studies or reports on pongamol in the treatment of neurodegenerative diseases, especially AD.…”

Section: Introductionmentioning

confidence: 99%

Pongamol Alleviates Neuroinflammation and Promotes Autophagy in Alzheimer’s Disease by Regulating the Akt/mTOR Signaling Pathway

Hu,

Wu,

et al. 2024

J. Agric. Food Chem.

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Alzheimer's disease (AD), one of the neurodegenerative disorders, is highly correlated with the abnormal hyperphosphorylation of Tau and aggregation of β-amyloid (Aβ). Oxidative stress, neuroinflammation, and abnormal autophagy are key drivers of AD and how they contribute to neuropathology remains largely unknown. The flavonoid compound pongamol is reported to possess a variety of pharmacological activities, such as antioxidant, antibacterial, and anti-inflammatory. This study investigated the neuroprotective effect and its mechanisms of pongamol in lipopolysaccharide (LPS)-induced BV2 cells, d-galactose/ sodium nitrite/aluminum chloride (D-gal/NaNO 2 /AlCl 3 )-induced AD mice, and Caenorhabditis elegans models. Our research revealed that pongamol reduced the release of inflammatory factors IL-1β, TNF-α, COX-2, and iNOS in LPS-induced BV2 cells. Pongamol also protected neurons and significantly restored memory function, inhibited Tau phosphorylation, downregulated Aβ aggregation, and increased oxidoreductase activity in the hippocampus of AD mice. In addition, pongamol reversed the nuclear transfer of NF-κB and increased the levels of Beclin 1 and LC3 II/LC3 I. Most importantly, the anti-inflammatory and promoter autophagy effects of pongamol may be related to the regulation of the Akt/mTOR signaling pathway. In summary, these results showed that pongamol has a potential neuroprotective effect, which greatly enriched the research on the pharmacological activity of pongamol for improving AD.

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A feasible method for isolation of pongamol from karanja (Pongamia pinnata) seed and its anti-inflammatory activity

Cited by 12 publications

References 50 publications

Enhancing grain drying methods with hyperspectral imaging technology: A visualanalysis

Enhancing grain drying methods with hyperspectral imaging technology: A visualanalysis

Encapsulation, release and insecticidal activity of Pongamia pinnata (L.) seed oil

Pongamol Alleviates Neuroinflammation and Promotes Autophagy in Alzheimer’s Disease by Regulating the Akt/mTOR Signaling Pathway

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