A Feasibility Trial of Tamoxifen Chemoprevention of Breast Cancer in Great Britain

Powles, Trevor J.; Davey, Jane B.; McKinna, A

doi:10.3109/07357908809082130

Cited by 6 publications

(1 citation statement)

References 10 publications

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“…O conceito de SERM nasceu a partir de constatações feitas com o tamoxifeno. Alguns estudos mostraram que o tamoxifeno previne parcialmente a perda óssea nas mulheres menopausadas e promove uma redução sérica do colesterol (63,64), mas a utilização prolongada do tamoxifeno aumenta o risco de câncer de endométrio.…”

Section: Serms (Selective Estrogen Receptor Modulators)unclassified

Por que estrógeno e raloxifeno melhoram a densidade mineral óssea?: mecanismo de ação do estrógeno e de um modulador seletivo do receptor de estrógeno (SERM) no osso

Ramalho

Lazaretti‐Castro

Cohen‐Solal

et al. 2000

Arq Bras Endocrinol Metab

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Estrogen deficiency is responsible for increased bone turnover in the postmenopausal period, and it can be prevented by estrogen replacement therapy. The way by which estrogen acts on bone cells is not fully understood and there are still many unsolved questions: (1) What is the target-cell of estrogen in bone? Estrogen receptor has been described in monocyte, osteoclast, bone marrow stromal cell and osteoblast, but it is still not clear what cell mediates the effect of estrogen in bone. (2) What are the mediators of estrogen action on bone? There is some controversy about the role of interleukin-6; most of the positive results were in animals, not in human; other cytokines are also involved, as tumoral necrosis factor and interleukin-1. (3) Is the anti-osteoclast effect of estrogen related to the apoptosis of osteoclast precursors? Some authors had already reported that estrogen increase apoptosis of osteoclasts precursors in animals, but

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Section: Serms (Selective Estrogen Receptor Modulators)unclassified