A feasibility study of MR elastography in the diagnosis of prostate cancer at 3.0T

Li, Sa-Ying; Chen, Min; Wang, Wenchao; Zhao, Weifeng; Wang, Qianqian; Zhao, Xüna; Zhou, Cheng

doi:10.1258/ar.2010.100276

Cited by 59 publications

(43 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most studies rely on biopsy and sectioned whole mount slides as a gold standard (7,10). Unfortunately, in these methods the spatial information is lost and the researcher has to guess the location of the biopsy or the section of the whole mount from the pathology report.…”

Section: Discussionmentioning

confidence: 99%

“…Previously, MRE of human in vivo prostate cancer has been demonstrated by only two groups. Li et al (10) used a trans-pelvic excitation at 100 Hz with a 4 mm resolution and showed a positive correlation between biopsy cores graded by the Gleason score and elasticity of prostate cancer (r = 0.91, p < 0.01) in 18 patients. They found that mean elasticity was significantly higher in the lesions with prostate cancer (6.55 ± 0.47 kPa) than in regions with prostatitis (1.99 ± 0.66 kPa).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

MR elastography of prostate cancer: quantitative comparison with histopathology and repeatability of methods

et al. 2014

View full text Add to dashboard Cite

The purpose of this work was to assess trans-perineal prostate magnetic resonance elastography (MRE) for (1) repeatability in phantoms/volunteers and (2) diagnostic power as correlated with histopathology in prostate cancer patients. The three-dimensional (3D) displacement field was obtained using a fractionally encoded gradient echo sequence using a custom-made transducer. The repeatability of the method was assessed based on three repeat studies and by changing the driving frequency by 3% in studies on a phantom and six healthy volunteers. Subsequently, 11 patients were examined with MRE prior to radical prostatectomy. The areas under the receiver operating characteristic curves were calculated using a windowed voxel-to-voxel approach by comparing the 2D registered slides, masked with the Gleason score. For the repeatability study, the average intraclass correlation coefficient for elasticity images was 99% for repeat phantom studies, 98% for ±6 Hz phantom studies, 95% for volunteer repeat studies with 2 min acquisition time, 82% for ±2 Hz volunteer studies with 2 min acquisition time and 73% for repeat volunteer studies with 8 min acquisition time. For the patient study, the average elasticity was 8.2 ± 1.7 kPa in the prostate capsule, 7.5 ± 1.9 kPa in the peripheral zone (PZ), 9.7 ± 3.0 kPa in the central gland (CG) and 9.0 ± 3.4 kPa in the transition zone. In the patient study, cancerous tissue with Gleason score at least 3 + 3 was significantly (p < 0.05) different from normal tissue in 10 out of 11 cases with tumors in the PZ, and 6 out of 9 cases with tumors in the CG. However, the overall case-averaged area under the curve was 0.72 in the PZ and 0.67 in the CG. Cancerous tissue was not always stiffer than normal tissue. The inversion algorithm was sensitive to (i) vibration amplitude and displacement nodes and (ii) misalignment of the 3D wave field due to subject movement.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

MR elastography of prostate cancer: quantitative comparison with histopathology and repeatability of methods

et al. 2014

View full text Add to dashboard Cite

show abstract

“…MRI elastography technology was also developed (S. Li et al, 2011), but here only ultrasound is described. Back-scattered ultrasound waves are displaced with compression or decompression of tissue (approximately 2%), harder areas showing less displacement compared to softer (Salomon et al, 2008).…”

Section: Elastographymentioning

confidence: 99%

Future of Prostate Biopsy: Who Will Get It and How?

Hajdinjak¹

2011

Prostate Cancer - Diagnostic and Therapeutic Advances

View full text Add to dashboard Cite

“…In vivo MRE has been successfully applied to reveal the stiffness of a variety of human tissues and organs such as the brain [4] [6], breast [4] [7], liver [4] [8], prostate [9] [10], and skeletal muscles [4] [10].…”

Section: Introductionmentioning

confidence: 99%

Partial Volume Effect on MR Elastography

Ito¹,

Numano²,

Mizuhara³

et al. 2017

OJMI

View full text Add to dashboard Cite

Magnetic resonance elastography (MRE) allows the quantitative assessment of the stiffness of tissues based on the tissue response to oscillatory shear stress. Shear wave displacements of the tissues are encoded as phase shifts and converted to stiffness (elastogram). Generally, a partial volume effect occurs when different materials are encompassed on the same voxel. In MRE, however, the partial volume effect occurs even if the voxel is filled with the same materials because wave displacements due to vibrations are spatially distributed. The purpose of this study was to investigate how the partial volume effect can affect the phase shift and the elastogram in MRE. We assumed that the partial volume effect appears only in the slice thickness direction and performed a simulation and MRE experiment with various slice thicknesses (1 -19 mm), two types of imaging plane (coronal and axial) and two types of vibration frequency (100 and 200 Hz). The results of the simulation and the MRE experiment were similar, and indicated that the phase shift and the elastogram changed variously depending on the slice thickness, the wave pattern and the vibration frequency, even if the voxel was filled with the same material. To reduce the partial volume effect, it is necessary to perform the MRE under the following conditions: Use a wave pattern which barely causes this artefact, a smaller voxel size and a lower vibration frequency.

show abstract

A feasibility study of MR elastography in the diagnosis of prostate cancer at 3.0T

Abstract: MR elastography can be used to visualize the difference in stiffness between prostate cancer and benign prostatic disease. It is a new imaging method with potential in the diagnosis of prostate cancer.

Cited by 59 publications

References 16 publications

MR elastography of prostate cancer: quantitative comparison with histopathology and repeatability of methods

MR elastography of prostate cancer: quantitative comparison with histopathology and repeatability of methods

Future of Prostate Biopsy: Who Will Get It and How?

Partial Volume Effect on MR Elastography

Contact Info

Product

Resources

About