A Feasibility Study of Mepitel Film for the Prevention of Breast Radiation Dermatitis in a Canadian Center

MASCC clinical practice guidelines for the prevention and management of acute radiation dermatitis: part 1) systematic review

“…There was inconsistent evidence supporting the use of StrataXRT, silver nylon dressings, Cavilon No-Sting barrier film, and other interventions in ARD prevention. 35 , 62 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 Laser therapy 10 (5) 576 (43.5; 25–120) Photobiomodulation (low-level laser) therapy (9); Photomagnetic therapy (1) Breast (7); Head and neck (3) Photobiomodulation (low-level laser) therapy was generally found to be effective in ARD prevention. 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 Natural and miscellaneous agents 51 (39) 5290 (62; 1–686) Aloe vera (6); Curcumin (turmeric) (6); Calendula (marigold) (4); Chamomilla recutita (3); Other (38) Breast (32); Head and neck (12); Multiple (5); NS (2) Topical olive oil was generally found to be effective in ARD prevention.…”

“…Among studies investigating barrier films and dressings, seven non-randomized studies and 18 RCTs were identified, for a total of 25 studies 35 , 62 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 ( Appendix C, Table 3 ). Promising results were found in studies on polyurethane film (Hydrofilm ®), 74 , 96 topical film-forming gel (StrataXRT ®), 75 , 76 , 77 silicone-based polyurethane (Mepitel ® film), 78 , 79 , 84 , 85 , 86 3M Cavilon No Sting barrier film, 87 and others.…”

Radiodermatitis Treatment: Traditional Review

“…Mepitel ® filminin 3. derece RD'yi tamamen engellediği belirtilmiş ancak RD için standart profilaksiye karşı etkinliğini doğrulamak amacıyla daha fazla araştırmaya ihtiyaç olduğu sonucuna varılmıştır. 62 RD tedavisi için 3 etkili yapı (glukan, hidroksiprolisilan C, matrixyl) içeren ve ticari bir ürün olan Thêta-Cream ® (TheraCosm GmbH, Almanya) içeriğindeki glukan, makrofajların fagositozunu ve oksidatif stresi azaltan biyolojik ajandır. Hidroksiprolisilan C, serbest oksijen radikallerine karşı derinin duyarlılığını azaltır; lipidlerin ve kollajen liflerinin yeniden düzenlenmesine yardımcı olur.…”

Modern Dressings in Prevention and Therapy of Acute and Chronic Radiation Dermatitis—A Literature Review

“…Complete prevention of RTOG grade 3 ARD and a significant reduction in grade 2 cases were obtained. Moist desquamation, however, could not be completely prevented [24]. A retrospective review carried out by Oshin et al showed significantly lower rates of moist desquamation after prophylactic use of Mepitel film in patients with breast cancer [25].…”

“…The following supporting information can be downloaded at: https: //www.mdpi.com/article/10.3390/pharmaceutics14061204/s1, Table S1: Proposed T.I.M.E. wound bed preparation for acute and chronic radiation dermatitis, Table S2: Dressings for prevention and treatment of acute radiation dermatitis [19][20][21][22][23][24][25][26][27][28][29][30][31][33][34][35][36][37][38][39][40][42][43][44][45][47][48][49][50][52][53][54][55][56]74].…”