A Fatal Reaction Caused by Implantation of Adult Parental Spleen Tissue in Irradiated F1 Mice

The Induction of Graft Versus Host Disease in Mice Treated With Cyclophosphamide

“…Outwardly it strongly resembled the graft versus host disorders previously described in adult animals, especially the "acute killing killing effect" noted in irradiated animals given allogeneic bone marrow and lymph node ceUs (6,11,19,20). The gross autopsy findings of pallor, thymus and lymph node atrophy, and a variable enlargement or atrophy of the spleen were also similar.…”

“…It is of interest that the relative potency of these tissues to initiate graft versus host disease is analogous to their ability to produce humoral antibody when adoptively transferred to cyclophosphamide-treated mice (13) and to their ability to induce tolerance and runt disease in neonatal mice (35). Similarly, it has been shown that foreign lymphoid cells are more effective than comparable numbers of cells from bone marrow in initiating graft versus host disease in lethally X-irradiated recipient animals (6,11,19,20).…”

Role of Immunologic Disturbance in Human Oncogenesis: Some Facts and Fancies

“…The proliferative response is followed by a cytocidal attack upon the normal cells of the host, which is particularly manifest i'n the lymphoid tissues, leading to their progressive and profound depletion (Schwartz, Upton and Congdon, 1957;Billingham, 1958;Trentin, 1958;Kaplan and Rosston, 1959).…”

The Effect of Presensitization of Parental Donors on Graft-Versus-Host Disease in Irradiated F1 Hybrid Mice

“…An excellent general review of GVH reactions has been made by Simonsen GVH disease induced in 1C3F1 hybrid mice after irradiation and injection of parental spleen or bone marrow cells was noted previously to be mild compared to that occurring in some other strain combinations. However, presensitization of the parental donor by spleen cells of the F1 or of the reciprocal parent results in a severe GVH reaction under the same conditions (2)(3)(4)(5).…”