A fatal intoxication case involving ropinirole

Duband, S.; Bidat, Carolyne; Gaillard, Yvan; Rochet, Max; Camdessanché, Jean‐Philippe; Péoc’h, Michel

doi:10.1016/j.jflm.2012.04.013

Cited by 7 publications

(2 citation statements)

References 20 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hardness of the prepared tablets was found in the range of 6.3±0.013 to 6.5±0.46 kg/cm 2 . Friability of all the tablets was found below 1%.…”

Section: Hardness and Friabilitymentioning

confidence: 97%

“…1 A specific non-ergoline dopamine D2 receptor agonist, ropinirole is often employed in the treatment of PD worldwide. 2 Repeated oral administration of long acting dopamine agonist ropinirole is known to cause fluctuating plasma levels leading to low levels of diskinesia. Controlled release formulations of ropinirole were found to be resulting in prolonged reversal of motor deficit with reduced diskinesia, smooth plasma concentration-time levels and better tolerability.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Application of 32 Factorial D-Optimal Design in Formulation of Porous Osmotic Pump Tablets of Ropinirole; An Anti-Parkinson’s Agent

Narayanan¹,

George²,

L³

2017

JYP

View full text Add to dashboard Cite

Objective: In the present study, our objective was to develop porous osmotic pump tablets of an anti-Parkinson's agent, ropinirole. It also aimed to demonstrate the applicability of factorial designs and there by a statistical optimization in developing a controlled drug releasing device. Methods: A 3 2 factorial D-optimal study design was adopted to identify an optimized formulation. Tablets were prepared by direct compression using varying amounts of microcrystalline cellulose (MCC) and sodium chloride, followed by coating with semipermeable membrane of cellulose acetate (CA) containing polyethylene glycol (PEG) 400 as a pore former. The plasticity of the membranes was adjusted using castor oil. All the formulations were evaluated for various physical parameters including in vitro drug release and the effect of osmogent and pore former were also studied. Drug release kinetics studies such as zero order, first order and Korsmeyer Peppas were carried out and compared. ANOVA in drug release of all the formulations were determined. Formulations were optimized by using numerical optimization technique to achieve a controlled zero order release of ropinirole for 12 hours. Results: Drug release from the optimized formulation containing 20%w/w of PEG, without osmogent was not significantly affected by change in pH or agitation of the dissolution medium. The mechanism of drug release was further confirmed by studying the effect of osmotic pressure on drug release. Conclusion: The porous osmotic pump tablets of ropinirole can provide prolonged, controlled and GI environment-independent drug release. A software based optimization is helpful and reliable in developing porous osmotic pump tablets.

show abstract

“…Hardness of the prepared tablets was found in the range of 6.3±0.013 to 6.5±0.46 kg/cm 2 . Friability of all the tablets was found below 1%.…”

Section: Hardness and Friabilitymentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Application of 32 Factorial D-Optimal Design in Formulation of Porous Osmotic Pump Tablets of Ropinirole; An Anti-Parkinson’s Agent

Narayanan¹,

George²,

L³

2017

JYP

View full text Add to dashboard Cite

show abstract

Vitreous humor analysis for the detection of xenobiotics in forensic toxicology: a review

et al. 2015

View full text Add to dashboard Cite

Vitreous humor (VH) is a gelatinous substance contained in the posterior chamber of the eye, playing a mechanical role in the eyeball. It has been the subject of numerous studies in various forensic applications, primarily for the assessment of postmortem interval and for postmortem chemical analysis. Since most of the xenobiotics present in the bloodstream are detected in VH after crossing the selective blood-retinal barrier, VH is an alternative matrix useful for forensic toxicology. VH analysis offers particular advantages over other biological matrices: it is less prone to postmortem redistribution, is easy to collect, has relatively few interfering compounds for the analytical process, and shows sample stability over time after death. The present study is an overview of VH physiology, drug transport and elimination. Collection, storage, analytical techniques and interpretation of results from qualitative and quantitative points of view are dealt with. The distribution of xenobiotics in VH samples is thus discussed and illustrated by a table reporting the concentrations of 106 drugs from more than 300 case reports. For this purpose, a survey was conducted of publications found in the MEDLINE database from 1969 through April 30, 2015.

show abstract