“…Nausea and vomiting have occurred, with seizures reported infrequently. Individual reports of hypertension, pulmonary oedema, and cardiac arrhythmias have generally been in patients with pre-existing heart disease undergoing cardiac surgery,10 and the role of naloxone in two reported cases of pulmonary oedema in healthy young men11 12 has since been questioned 13. The National Poisons Information Service in London reported that it had never been informed of a suspected adverse reaction to naloxone despite being contacted by about 800 cases of opioid poisoning each year 14…”