A fatal case of necrotising pneumonia due to community‐associated methicillin‐resistant Staphylococcus aureus

Risson, David C.; O’Connor, Enda; Guard, Roger W.; Schooneveldt, Jacqueline; Nimmo, Graeme R.

doi:10.5694/j.1326-5377.2007.tb01002.x

Cited by 29 publications

(19 citation statements)

References 8 publications

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“…Multiple case reports104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 [III] and series of 2–11 patients,119 120 121 122 123 124 [II] both from the UK and worldwide, describe episodes of CAP caused by S aureus (either methicillin-sensitive S aureus (MSSA) or MRSA) capable of production of the Panton-Valentine Leucocidin toxin. Severe illness—with high mortality, bilateral lung shadowing and frequent lung cavitation—is common to these reports.…”

Section: Section 3 Aetiology and Epidemiologymentioning

confidence: 99%

BTS guidelines for the management of community acquired pneumonia in adults: update 2009

Lim

Baudouin²,

George³

et al. 2009

Thorax

1,164

1,073

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Section: Section 3 Aetiology and Epidemiologymentioning

confidence: 99%

BTS guidelines for the management of community acquired pneumonia in adults: update 2009

Lim

Baudouin²,

George³

et al. 2009

Thorax

1,164

1,073

View full text Add to dashboard Cite

“…A 23-year-old woman presented to an emergency department with acute radicular lower back pain and was discharged despite tachycardia and fever [48]. 2 days later, she presented again with continued back pain, shortness of breath, vomiting, myalgia, fever, sweating, dry cough, and anterior pleuritic chest pain.…”

Section: Case Studiesmentioning

confidence: 99%

“…Infections with ST93-MRSA predominantly manifest as SSTI, but an enhanced clinical virulence as evidenced by reports of severe invasive infection such as necrotizing pneumonia, deep-seated abscess, osteomyelitis, septic arthritis, and septicemia has also been suggested [48, 52]. ST93 has now also been described in New Zealand and the UK and many of these cases could be epidemiologically linked to Australia [55].…”

Section: Case Studiesmentioning

confidence: 99%

Community-Associated Methicillin-Resistant Staphylococcus aureus Case Studies

Sowash

Uhlemann

2013

Methods in Molecular Biology

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Over the past decade, the emergence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has changed the landscape of S. aureus infections around the globe. Initially recognized for its ability to cause disease in young and healthy individuals without healthcare exposures as well as for its distinct genotype and phenotype, this original description no longer fully encompasses the diversity of CA-MRSA as it continues to expand its niche. Using four case studies, we highlight a wide range of the clinical presentations and challenges of CA-MRSA. Based on these cases we further explore the globally polygenetic background of CA-MRSA with a special emphasis on generally less characterized populations.

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“…Infants in the neonatal intensive care unit (NICU) developed MRSA pneumonia at a younger age, had a lower birth weight and a longer duration of positive cultures than infants with MSSA [8, 9]. MRSA pneumonia in adults is characterized by a strong inflammatory response including a neutrophilic influx into the lung, pulmonary edema, loss of alveolar architecture and hemorrhage [10, 11]. The pathology caused by MRSA is due to the many virulence factors produced by the bacteria as well as to the overwhelming host immune response to the infection.…”

Section: Introductionmentioning

confidence: 99%

A Neonatal Murine Model of MRSA Pneumonia

et al. 2017

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Pneumonia due to methicillin-resistant Staphylococcus aureus (MRSA) is a significant cause of morbidity and mortality in infants particularly following lower respiratory tract viral infections such as Respiratory Syncytial Virus (RSV). However, the mechanisms by which co-infection of infants by MRSA and RSV cause increased lung pathology are unknown. Because the infant immune system is qualitatively and quantitatively different from adults we developed a model of infant MRSA pneumonia which will allow us to investigate the effects of RSV co-infection on disease severity. We infected neonatal and adult mice with increasing doses of MRSA and demonstrate that neonatal mice have delayed kinetics in clearing the bacteria in comparison to adult mice. There were differences in recruitment of immune cells into the lung following infection. Adult mice exhibited an increase in neutrophil recruitment that coincided with reduced bacterial titers followed by an increase in macrophages. Neonatal mice, however, exhibited an early increase in neutrophils that did not persist despite continued presence of the bacteria. Unlike the adult mice, neonatal mice failed to exhibit an increase in macrophages. Neonates exhibited a decrease in phagocytosis of MRSA suggesting that the decrease in clearance was partially due to deficient phagocytosis of the bacteria. Both neonates and adults responded with an increase in pro-inflammatory cytokines following infection. However, in contrast to the adult mice, neonates did not express constitutive levels of the anti-microbial peptide Reg3γ in the lung. Infection of neonates did not stimulate expression of the co-stimulatory molecule CD86 by dendritic cells and neonates exhibited a diminished T cell response compared to adult mice. Overall, we have developed a neonatal model of MRSA pneumonia that displays a similar delay in bacterial clearance as is observed in the neonatal intensive care unit and will be useful for performing co-infection studies.

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A fatal case of necrotising pneumonia due to community‐associated methicillin‐resistant Staphylococcus aureus

Cited by 29 publications

References 8 publications

BTS guidelines for the management of community acquired pneumonia in adults: update 2009

BTS guidelines for the management of community acquired pneumonia in adults: update 2009

Community-Associated Methicillin-Resistant Staphylococcus aureus Case Studies

A Neonatal Murine Model of MRSA Pneumonia

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