A Fatal Case of Hypertriglyceridemia-Induced Acute Pancreatitis in a Patient With Diabetic Ketoacidosis

Abstract

Diabetic ketoacidosis (DKA) with coexisting hypertriglyceridemia-induced acute pancreatitis is a rare yet potentially life-threatening condition. This report describes a patient with no history of diabetes who presented with DKA and coexisting acute pancreatitis secondary to severe hypertriglyceridemia. The patient did not respond to standard DKA management or plasmapheresis, developed acute respiratory distress syndrome (ARDS), and eventually expired.

Acute Pancreatitis, Hypertriglyceridemia, and Diabetic Ketoacidosis: A Life-Threatening Triad

“…Patients diagnosed with acute pancreatitis and DKA had higher levels of HTG and more extended hospital stays and complications compared to those without DKA [7]. Narala et al have described a case of acute pancreatitis induced by HTG concurrent with DKA as an initial manifestation of type 2 DM [8]. Naqvi S et al reported a case of the life-threatening triad of acute pancreatitis, DKA, and HTG due to poor compliance with DM treatment measures [9].…”

“…The management of HTG-induced acute pancreatitis primarily involves reducing serum triglyceride levels. This can be achieved through dietary modification, lipid-lowering medications, and, in severe cases, therapeutic plasma exchange or plasmapheresis [7,8]. Intravenous hydration, pain management, and nutritional support are essential components of pancreatitis management [9].…”