A Fatal Case of Acute Respiratory Failure Caused byMycobacterium massiliense

Abstract

Few recent reports have indicated that Mycobacterium massiliense causes various infections including respiratory infection. However, there is scarce information on the clinical significance, natural history of the infection, and therapeutic strategy. This report describes a case of an immunocompetent old man infected by M. massiliense that causes acute respiratory failure. In light of the general courses of non-tuberculous mycobacterium infections, rapid progression and fatality are very rare and odd. In addition, we discuss the biological and pathological properties of M. massiliense with the review of cases reported previously including our fatal one.

A Case of Skin and Soft Tissue Infection byMycobacterium massiliense

“…Mycobacterium massiliense (M. massiliense)는 균동정 기술 발달에 따라 M. abscessus로부터 분리된 균주로 주로 호흡기 감염과 관련하여 보고가 많으나 [1,2], 피부 연부 조직 감염은 일본과 우리나라에서 단지 소수 증례만이 보고되었을 뿐이 다 [3,4]. 다른 비정형 결핵균과 마찬가지로 지금까지 발표된…”

Mycobacterium massiliense Bacteremia as a Consequence of M. massiliense Pneumonia in a Patient with Acute Lymphoblastic Leukemia

“…However, M. massiliense sepsis was fatal in the first two reported cases (9,10). Although M. massiliense has been isolated from respiratory specimens from a few bacteremia cases (10,11), M. massiliense is a frequent colonizer of immunosuppressed patients (7,14,21). Virulence causing fatal outcomes in cases of bacteremia has not yet been resolved.…”