A Fast Tuning Method for Microwave Filter Using Vf-Asm Technology

Zhang, Yongliang; Su, Tao; Li, Zhipeng; Liang, Chuntao

doi:10.2528/pierm13012201

Cited by 6 publications

(5 citation statements)

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“…5,6 Chemoradiotherapy can increase the immunogenic properties of tumor cells, thereby inc reasing their v ulnerability to cytotoxic lymphocytes 7,8 and inducing expression of programmed death-ligand 1 on tumor cells, which can lead to an immunosuppressive microenvironment. 9,10 We hypothesized that the addition of anti-programmed death 1 therapy to neoadjuvant chemoradiotherapy could increase CD8 Patients were randomized to receive 6 cycles of FOLFOX (5-fluorouracil, leucovorin, and oxaliplatin) followed by chemoradiotherapy (825 mg/m 2 of capecitabine twice daily concurrently with 4500 cGy in 25 fractions for 5 weeks plus a 540-cGy boost in 3 fractions) starting 3 to 4 weeks after FOLFOX (CA) or the same dosage of FOLFOX followed by the same chemoradiotherapy regimen in combination with 200 mg of pembrolizumab every 3 weeks starting on day 1 of chemoradiotherapy for up to 6 doses (PA). Surgery was performed 8 to 12 weeks after the last dose of radiotherapy (eFigure in Supplement 2).…”

Section: Meaningmentioning

confidence: 99%

Use of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer

et al. 2021

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IMPORTANCETotal neoadjuvant therapy (TNT) is often used to downstage locally advanced rectal cancer (LARC) and decrease locoregional relapse; however, more than one-third of patients develop recurrent metastatic disease. As such, novel combinations are needed.OBJECTIVE To assess whether the addition of pembrolizumab during and after neoadjuvant chemoradiotherapy can lead to an improvement in the neoadjuvant rectal (NAR) score compared with treatment with FOLFOX (5-fluorouracil, leucovorin, and oxaliplatin) and chemoradiotherapy alone. DESIGN, SETTING, AND PARTICIPANTSIn this open-label, phase 2, randomized clinical trial (NRG-GI002), patients in academic and private practice settings were enrolled. Patients with stage II/III LARC with distal location (cT3-4 Յ 5 cm from anal verge, any N), with bulky disease (any cT4 or tumor within 3 mm of mesorectal fascia), at high risk for metastatic disease (cN2), and/or who were not candidates for sphincter-sparing surgery (SSS) were stratified based on clinical tumor and nodal stages. Trial accrual opened on August 1, 2018, and ended on May 31, 2019. This intent-to-treat analysis is based on data as of August 2020.INTERVENTIONS Patients were randomized (1:1) to neoadjuvant FOLFOX for 4 months and then underwent chemoradiotherapy (capecitabine with 50.4 Gy) with or without intravenous pembrolizumab administered at a dosage of 200 mg every 3 weeks for up to 6 doses before surgery. MAIN OUTCOMES AND MEASURESThe primary end point was the NAR score. Secondary end points included pathologic complete response (pCR) rate, SSS, disease-free survival, and overall survival. This report focuses on end points available after definitive surgery (NAR score, pCR, SSS, clinical complete response rate, margin involvement, and safety).RESULTS A total of 185 patients (126 [68.1%] male; mean [SD] age, 55.7 [11.1] years) were randomized to the control arm (CA) (n = 95) or the pembrolizumab arm (PA) (n = 90). Of these patients, 137 were evaluable for NAR score (68 CA patients and 69 PA patients). The mean (SD) NAR score was 11.53 (12.43) for the PA patients (95% CI, 8.54-14.51) vs 14.08 (13.82) for the CA patients (95% CI, 10.74-17.43) (P = .26). The pCR rate was 31.9% in the PA vs 29.4% in the CA (P = .75). The clinical complete response rate was 13.9% in the PA vs 13.6% in the CA (P = .95). The percentage of patients who underwent SSS was 59.4% in the PA vs 71.0% in the CA (P = .15). Grade 3 to 4 adverse events were slightly increased in the PA (48.2%) vs the CA (37.3%) during chemoradiotherapy. Two deaths occurred during FOLFOX: sepsis (CA) and pneumonia (PA). No differences in radiotherapy fractions, FOLFOX, or capecitabine doses were found.CONCLUSIONS AND RELEVANCE Pembrolizumab added to chemoradiotherapy as part of total neoadjuvant therapy was suggested to be safe; however, the NAR score difference does not support further study.

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Section: Meaningmentioning

confidence: 99%

Use of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer

et al. 2021

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“…In [33], the low degree filters are tuning by the VF-ASM technique. Literature [34] shows the validity of this method for the higher degree filters. Although the method in [33,34] is time consuming, they suitable for the automated filter tuning.…”

Section: Comparison and Discussionmentioning

confidence: 99%

“…Literature [34] shows the validity of this method for the higher degree filters. Although the method in [33,34] is time consuming, they suitable for the automated filter tuning. The method proposed in this paper is fast and easy to reproduce.…”

Section: Comparison and Discussionmentioning

confidence: 99%

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A Hybrid Computer-Aided Tuning Method for Microwave Filters

Zhang¹,

Su²,

Li³

et al. 2013

PIER

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Abstract-A hybrid tuning method for microwave filters is presented in this paper. This novel tuning technique is based on the combination of the Cauchy method and aggressive space mapping (ASM) technique. Cauchy method is applied to determine the characteristic polynomials of the filter's response, then the parameters (coupling matrix) of the low-pass prototype is extracted from the characteristic polynomials. The aggressive space mapping is used to optimized the fine model to guarantee that each step of a tuning is always in the right direction. The validity is verified by two examples. One deals with the fourresonator cross-coupled filter and the other one is an direct coupled six-resonator filter.

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“…In this section, experiments were carried out with an eighth-order cavity filter [29], the model of which is illustrated in Figure 12. The metrics are as follows, with a center frequency of 2.0693 GHz and a bandwidth of 110 MHz, and the geometrical parameters to be optimized are H = [p 1 , p 2 , p 3 , p 4 , p 5 , p 6 , p 7 , p 8 ] T .…”

Section: Eighth-order Cavity Filtermentioning

confidence: 99%

Accurate Design of Microwave Filter Based on Surrogate Model-Assisted Evolutionary Algorithm

Zhang

Wang

et al. 2022

Electronics

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Filter optimization problems involve time-consuming simulations and many variables in the design. These problems require a large amount of computation. This paper proposes an adaptive online updating 1D convolutional autoencoders (AOU-1D-CAE) surrogate model for solving this computationally expensive problem. In the optimization process, an adaptive update surrogate mapping between input variables and output objectives is constructed within the surrogate model AOU-1D-CAE framework. AOU-1D-CAE can replace electromagnetic (EM) simulation software for data collection, and select and automatically use the accumulated data as training samples to train the AOU-1D-CAE surrogate model. With more and more training samples, the learning ability of the surrogate model is also becoming stronger and stronger. The experimental results show that the data collection efficiency of AOU-1D-CAE is greatly improved, and the automatic update of the sample set improves the prediction performance of the surrogate model. In this paper, the optimization framework is AOU-1D-CAE-assisted particle swarm optimization (PSO), and the surrogate model assists PSO to find the global optimal solution. In the PSO stage, PSO automatically updates and saves the optimal solution, and takes the optimal solution of each stage as the initial solution of the next optimization stage to avoid falling into the local optimal solution. The optimization time is greatly saved and the optimization efficiency is improved. The continuous iteration of PSO also improves the prediction accuracy of the surrogate model. The efficiency of the proposed surrogate model is demonstrated by using two cavity filters as examples.

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A Fast Tuning Method for Microwave Filter Using Vf-Asm Technology

Cited by 6 publications

References 20 publications

Use of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer

Use of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer

A Hybrid Computer-Aided Tuning Method for Microwave Filters

Accurate Design of Microwave Filter Based on Surrogate Model-Assisted Evolutionary Algorithm

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