2016
DOI: 10.1186/s12859-016-1365-2
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A fast exact sequential algorithm for the partial digest problem

Abstract: BackgroundRestriction site analysis involves determining the locations of restriction sites after the process of digestion by reconstructing their positions based on the lengths of the cut DNA. Using different reaction times with a single enzyme to cut DNA is a technique known as a partial digestion. Determining the exact locations of restriction sites following a partial digestion is challenging due to the computational time required even with the best known practical algorithm.ResultsIn this paper, we introd… Show more

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Cited by 15 publications
(10 citation statements)
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References 18 publications
(19 reference statements)
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“…However, there exist examples with exponential runtime [4,26]. Abbas and Bahig [27] later demonstrated that some of the worst-case scenarios could be avoided by performing a breadth-first search instead. An alternative to clever combinatorial search is to formulate the problem as a binary integer program [28][29][30], and then relax it to obtain a convex semidefinite program [5].…”
Section: Related Workmentioning
confidence: 99%
“…However, there exist examples with exponential runtime [4,26]. Abbas and Bahig [27] later demonstrated that some of the worst-case scenarios could be avoided by performing a breadth-first search instead. An alternative to clever combinatorial search is to formulate the problem as a binary integer program [28][29][30], and then relax it to obtain a convex semidefinite program [5].…”
Section: Related Workmentioning
confidence: 99%
“…Abbas and Bahig [1] introduced two exact sequential algorithms for PD problem. The first algorithm, BBb, is based on traverse the solution tree by using the breadth-first strategy from level 1 to n. The running time for the BBb algorithm is less than Skiena, Smith and Lemke algorithm.…”
Section: Best Known Exact Algorithmmentioning
confidence: 99%
“…Different algorithms are proposed to find the exact solution of PD problem [1, 2, 4-7, 9, 11-13, 15, 18]. Some of these algorithms are impractical algorithms, while the other algorithms are practical such as [1,9,18]. The first practical algorithm was designed by Skiena, Smith and Lemke [18] and ran in n 2 log n in the average case.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Abbas and Bahig [4] investigated the partial digestion problem by proposing two algorithm "branch and bound based on breadth" (BBb) and "branch and bound based on breadth two times" (BBb2). The latter requires less memory than BBb as the partial digestion problem is solved in two stages in breadth-first mode.…”
Section: Sequence Analysis and Ontologiesmentioning
confidence: 99%